cross-reactivity
Editor's Pick Observation | Therapeutics and PreventionDecline of Humoral Responses against SARS-CoV-2 Spike in Convalescent IndividualsWhile waiting for an efficient vaccine to protect against SARS-CoV-2 infection, alternative approaches to treat or prevent acute COVID-19 are urgently needed. Transfusion of convalescent plasma to treat COVID-19 patients is currently being explored; neutralizing activity in convalescent plasma is thought to play a central role in the efficacy of this treatment. Here, we observed that plasma neutralization activity decreased a few weeks...
Minireview | Molecular Biology and PhysiologyEnterobacterial Common Antigen: Synthesis and Function of an Enigmatic MoleculeThe outer membrane (OM) of Gram-negative bacteria poses a barrier to antibiotic entry due to its high impermeability. Thus, there is an urgent need to study the function and biogenesis of the OM. In Enterobacterales, an order of bacteria with many pathogenic members, one of the components of the OM is enterobacterial common antigen (ECA). We have known of the presence of ECA on the cell surface of Enterobacterales for...
Editor's Pick Research Article | Clinical Science and EpidemiologyInfluenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in AdultsIt is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 that the first infection(s) with influenza virus leaves a special immunological imprint which shapes immune responses to future infections with antigenically related influenza virus strains. Imprinting has been implicated in both protective effects as well as blunting of the immune response to vaccines. Despite the fact that this phenomenon...