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cross-reactivity

  • Open Access
    Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals
    Editor's Pick Observation | Therapeutics and Prevention
    Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals

    While waiting for an efficient vaccine to protect against SARS-CoV-2 infection, alternative approaches to treat or prevent acute COVID-19 are urgently needed. Transfusion of convalescent plasma to treat COVID-19 patients is currently being explored; neutralizing activity in convalescent plasma is thought to play a central role in the efficacy of this treatment. Here, we observed that plasma neutralization activity decreased a few weeks...

    Guillaume Beaudoin-Bussières, Annemarie Laumaea, Sai Priya Anand, Jérémie Prévost, Romain Gasser, Guillaume Goyette, Halima Medjahed, Josée Perreault, Tony Tremblay, Antoine Lewin, Laurie Gokool, Chantal Morrisseau, Philippe Bégin, Cécile Tremblay, Valérie Martel-Laferrière, Daniel E. Kaufmann, Jonathan Richard, Renée Bazin, Andrés Finzi
  • Open Access
    Enterobacterial Common Antigen: Synthesis and Function of an Enigmatic Molecule
    Minireview | Molecular Biology and Physiology
    Enterobacterial Common Antigen: Synthesis and Function of an Enigmatic Molecule

    The outer membrane (OM) of Gram-negative bacteria poses a barrier to antibiotic entry due to its high impermeability. Thus, there is an urgent need to study the function and biogenesis of the OM. In Enterobacterales, an order of bacteria with many pathogenic members, one of the components of the OM is enterobacterial common antigen (ECA). We have known of the presence of ECA on the cell surface of Enterobacterales for...

    Ashutosh K. Rai, Angela M. Mitchell
  • Open Access
    Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults
    Editor's Pick Research Article | Clinical Science and Epidemiology
    Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults

    It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 that the first infection(s) with influenza virus leaves a special immunological imprint which shapes immune responses to future infections with antigenically related influenza virus strains. Imprinting has been implicated in both protective effects as well as blunting of the immune response to vaccines. Despite the fact that this phenomenon...

    Philip Meade, Guillermina Kuan, Shirin Strohmeier, Hannah E. Maier, Fatima Amanat, Angel Balmaseda, Kimihito Ito, Ericka Kirkpatrick, Andres Javier, Lionel Gresh, Raffael Nachbagauer, Aubree Gordon, Florian Krammer
  • Open Access
    Research Article
    Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses
    Min Zhao, Kefang Liu, Jiejian Luo, Shuguang Tan, Chuansong Quan, Shuijun Zhang, Yan Chai, Jianxun Qi, Yan Li, Yuhai Bi, Haixia Xiao, Gary Wong, Jianfang Zhou, Taijiao Jiang, Wenjun Liu, Hongjie Yu, Jinghua Yan, Yingxia Liu, Yuelong Shu, Guizhen Wu, Aiping Wu, George F. Gao, William J. Liu
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