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Author Reply | Host-Microbe BiologyReply to Wood and Lee, “Precedence for the Role of Indole with Pathogens”
Research Article | Host-Microbe BiologyIndole Signaling at the Host-Microbiota-Pathogen InterfacePathogens sense and respond to several small molecules within the GI tract to modulate expression of their virulence repertoire. Indole is a signaling molecule produced by the gut microbiota. Here we show that indole concentrations are higher in the lumen, where the microbiota is present, than in the intestinal tissue. The enteric pathogens EHEC and C. rodentium sense...