chaperone
Research Article | Molecular Biology and PhysiologyMycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular ChaperoneM. tuberculosis infections are responsible for more than 1 million deaths per year. Developing effective strategies to combat this disease requires a greater understanding of M. tuberculosis biology. As in all cells, protein quality control is essential for the viability of...
Research Article | Host-Microbe BiologyA Chaperone for the Stator Units of a Bacterial FlagellumThe bacterial flagellum is a reversible rotating motor powered by ion transport through stator units, which also exert torque on the rotor component to turn the flagellum for motility. Species-specific adaptations to flagellar motors impact stator function to meet the demands of each species to sufficiently power flagellar rotation. We identified another evolutionary adaptation by discovering that FlgX of...
- Research ArticleHigh-Throughput Screening of Type III Secretion Determinants Reveals a Major Chaperone-Independent Pathway
Many bacterial pathogens use specialized nanomachines, including type III secretion systems, to directly inject virulence proteins (effectors) into host cells. Here, we present the first extensive analysis of chaperone dependence in the process of type III effector secretion, providing strong evidence for the existence of a previously unrecognized chaperone-independent pathway. This noncanonical pathway is likely common to many bacteria...