cell cycle
Research Article | Molecular Biology and PhysiologyControl of Bacillus subtilis Replication Initiation during Physiological Transitions and PerturbationsHigh-throughput, quantitative approaches have enabled the discovery of fundamental principles describing bacterial physiology. These principles provide a foundation for predicting the behavior of biological systems, a widely held aspiration. However, these approaches are often exclusively applied to the best-known model organism, E. coli. In this report, we...
Research Article | Molecular Biology and PhysiologyMolecular Basis and Ecological Relevance of Caulobacter Cell Filamentation in Freshwater HabitatsMany bacteria drastically change their cell size and morphology in response to changing environmental conditions. Here, we demonstrate that the freshwater bacterium Caulobacter crescentus and related species transform into filamentous cells in response to conditions that commonly occur in their natural habitat as a result of algal blooms during the warm summer months...
Research Article | Molecular Biology and PhysiologyDay/Night Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolaeEukaryotes acquired chloroplasts through an endosymbiotic event in which a cyanobacterium or a unicellular eukaryotic alga was integrated into a previously nonphotosynthetic eukaryotic cell. Photosynthesis by chloroplasts enabled algae to expand their habitats and led to further evolution of land plants. However, photosynthesis causes greater oxidative stress than mitochondrion-based respiration. In seed plants, cell division is...
- CommentaryTiming Is Everything
- Research ArticleDynamic Proteomics of Herpes Simplex Virus Infection
- Editor's Pick Research ArticleHost Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment
Legionella pneumophila has the ability to replicate within human macrophages and amoebal hosts. Here, we report that the host cell cycle influences L. pneumophila intracellular replication. Our data demonstrate that the G1 and G2/M phases of the host cell cycle are permissive for bacterial replication, while S phase is toxic for the bacterium. L. pneumophila replicates poorly within host...
- Research ArticleThe Toxoplasma Centrocone Houses Cell Cycle Regulatory Factors