catecholamine

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    Dopamine Is a Siderophore-Like Iron Chelator That Promotes <em>Salmonella enterica</em> Serovar Typhimurium Virulence in Mice
    Editor's Pick Research Article | Host-Microbe Biology
    Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice

    Here we show that dopamine increases bacterial iron incorporation and promotes Salmonella Typhimurium growth both in vitro and in vivo. These observations suggest the potential hazards of pharmacological catecholamine administration in patients with bacterial sepsis but also suggest that the inhibition of bacterial iron acquisition might provide a useful approach to antimicrobial therapy.

    Stefanie Dichtl, Egon Demetz, David Haschka, Piotr Tymoszuk, Verena Petzer, Manfred Nairz, Markus Seifert, Alexander Hoffmann, Natascha Brigo, Reinhard Würzner, Igor Theurl, Joyce E. Karlinsey, Ferric C. Fang, Günter Weiss
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