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caspofungin

  • Open Access
    Puf4 Mediates Post-transcriptional Regulation of Cell Wall Biosynthesis and Caspofungin Resistance in <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span>
    Research Article | Therapeutics and Prevention
    Puf4 Mediates Post-transcriptional Regulation of Cell Wall Biosynthesis and Caspofungin Resistance in Cryptococcus neoformans

    Cryptococcus neoformans is an environmental fungus that causes pulmonary and central nervous system infections. It is also responsible for 15% of AIDS-related deaths.

    Murat C. Kalem, Harini Subbiah, Jay Leipheimer, Virginia E. Glazier, John C. Panepinto
  • Open Access
    Signaling Pathways Governing the Caspofungin Paradoxical Effect in <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span>
    Commentary | Molecular Biology and Physiology
    Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus

    Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the...

    Nicolas Papon, Florent Morio, Dominique Sanglard
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span> Transcription Factors Involved in the Caspofungin Paradoxical Effect
    Research Article | Molecular Biology and Physiology
    Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect

    Aspergillus fumigatus, one of the most important human-pathogenic fungal species, is able to cause aspergillosis, a heterogeneous group of diseases that presents a wide range of clinical manifestations. Invasive pulmonary aspergillosis is the most serious pathology in terms of patient outcome and treatment, with a high mortality rate ranging from 50% to 95% primarily...

    Clara Valero, Ana Cristina Colabardini, Jéssica Chiaratto, Lakhansing Pardeshi, Patrícia Alves de Castro, Jaire Alves Ferreira Filho, Lilian Pereira Silva, Marina Campos Rocha, Iran Malavazi, Jonas Henrique Costa, Taícia Fill, Mário Henrique Barros, Sarah Sze Wah Wong, Vishukumar Aimanianda, Koon Ho Wong, Gustavo H. Goldman
  • Open Access
    Cell Wall Composition Heterogeneity between Single Cells in <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span> Leads to Heterogeneous Behavior during Antifungal Treatment and Phagocytosis
    Research Article | Molecular Biology and Physiology
    Cell Wall Composition Heterogeneity between Single Cells in Aspergillus fumigatus Leads to Heterogeneous Behavior during Antifungal Treatment and Phagocytosis

    The fungus Aspergillus fumigatus can cause invasive lung diseases in immunocompromised patients resulting in high mortality. Treatment using antifungal compounds is often unsuccessful. Average population measurements hide what is happening at the individual cell level. We set out to test what impact individual differences between the cell walls of fungal conidia have...

    Robert-Jan Bleichrodt, Peter Foster, Gareth Howell, Jean-Paul Latgé, Nick D. Read
  • Open Access
    The <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span> Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
    Research Article | Molecular Biology and Physiology
    The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

    Aspergillus fumigatus is an opportunistic human pathogen causing allergic reactions or systemic infections, such as invasive pulmonary aspergillosis in immunocompromised patients. The mitogen-activated protein kinase (MAPK) signaling pathways are essential for fungal adaptation to the human host. Fungal cell survival, fungicide tolerance, and virulence are highly...

    Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman
  • Open Access
    Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-<span class="sc">d</span>-Glucan Synthase Cause Clinically Important Echinocandin Resistance in <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span>
    Research Article | Molecular Biology and Physiology
    Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

    Resistance to first-line triazole antifungal agents among Aspergillus species has prompted the use of second-line therapy with echinocandins. As the number of Aspergillus-infected patients treated with echinocandins is rising, clinical observations of drug resistance are also increasing, indicating an emerging global health threat. Our knowledge regarding the development of clinical echinocandin resistance is largely...

    Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin
  • Open Access
    Research Article
    The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect
    Laure Nicolas Annick Ries, Marina Campos Rocha, Patrícia Alves de Castro, Rafael Silva-Rocha, Roberto Nascimento Silva, Fernanda Zanolli Freitas, Leandro José de Assis, Maria Célia Bertolini, Iran Malavazi, Gustavo H. Goldman
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