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Candida

  • Open Access
    Three Related Enzymes in <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence
    Research Article | Host-Microbe Biology
    Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence

    We show that the C. albicans ureohydrolases arginase (Car1), agmatinase (Agt1), and guanidinobutyrase (Gbu1) can orchestrate an arginase-independent route for polyamine production and that this is important for C. albicans growth and survival in microenvironments of the mammalian host.

    ...
    Katja Schaefer, Jeanette Wagener, Ryan M. Ames, Stella Christou, Donna M. MacCallum, Steven Bates, Neil A. R. Gow
  • Open Access
    Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to <em>Candida</em> Species
    Research Article | Host-Microbe Biology
    Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species

    Neutrophils are recognized to represent significant immune cell mediators for the clearance and elimination of the human-pathogenic fungal pathogen Candida. The sensing of fungi by innate cells is performed, in part, through lectin receptor recognition of cell wall components and downstream cellular activation by signaling components, including spleen tyrosine kinase (Syk). While the essential role of Syk in macrophages and...

    Paige E. Negoro, Shuying Xu, Zeina Dagher, Alex Hopke, Jennifer L. Reedy, Michael B. Feldman, Nida S. Khan, Adam L. Viens, Natalie J. Alexander, Natalie J. Atallah, Allison K. Scherer, Richard A. Dutko, Jane Jeffery, John F. Kernien, J. Scott Fites, Jeniel E. Nett, Bruce S. Klein, Jatin M. Vyas, Daniel Irimia, David B. Sykes, Michael K. Mansour
  • Open Access
    Mutations in <em>TAC1B</em>: a Novel Genetic Determinant of Clinical Fluconazole Resistance in <span class="named-content genus-species" id="named-content-1">Candida auris</span>
    Editor's Pick Research Article | Therapeutics and Prevention
    Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

    Candida auris is an emerging multidrug-resistant pathogen of global concern, known to be responsible for outbreaks on six continents and to be commonly resistant to antifungals. While the vast majority of clinical C. auris isolates are highly resistant to fluconazole, an essential part of the...

    Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
  • Open Access
    The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling
    Editor's Pick Research Article | Molecular Biology and Physiology
    The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling

    Fungi cause life-threatening infections and pose a serious threat to human health as there are very few effective antifungal drugs. Candida albicans is a major human fungal pathogen and cause of morbidity and mortality in immunocompromised individuals. A key trait that enables C. albicans virulence...

    Saif Hossain, Amanda O. Veri, Leah E. Cowen
  • Open Access
    Multiple Alternative Carbon Pathways Combine To Promote <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Stress Resistance, Immune Interactions, and Virulence
    Research Article | Host-Microbe Biology
    Multiple Alternative Carbon Pathways Combine To Promote Candida albicans Stress Resistance, Immune Interactions, and Virulence

    Candida albicans is a fungal pathogen and a significant cause of morbidity and mortality, particularly in people with defects, sometimes minor ones, in innate immunity. The phagocytes of the innate immune system, particularly macrophages and neutrophils, generally restrict this organism to its normal commensal niches, but...

    Robert B. Williams, Michael C. Lorenz
  • Open Access
    Comparative Genomics for the Elucidation of Multidrug Resistance in <span class="named-content genus-species" id="named-content-1">Candida lusitaniae</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae

    Antifungal resistance is an inevitable phenomenon when fungal pathogens are exposed to antifungal drugs. These drugs can be grouped in four distinct classes (azoles, candins, polyenes, and pyrimidine analogs) and are used in different clinical settings. Failures in therapy implicate the sequential or combined use of these different drug classes, which can result in some cases in the development of multidrug resistance (MDR). MDR is...

    Abhilash Kannan, Sandra A. Asner, Emilie Trachsel, Steve Kelly, Josie Parker, Dominique Sanglard
  • Open Access
    On the Emergence of <span class="named-content genus-species" id="named-content-1">Candida auris</span>: Climate Change, Azoles, Swamps, and Birds
    Opinion/Hypothesis | Host-Microbe Biology
    On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds

    The most enigmatic aspect of the rise of Candida auris as a human pathogen is that it emerged simultaneously on three continents, with each clade being genetically distinct. Although new pathogenic fungal species are described regularly, these are mostly species associated with single cases in individuals who are immunosuppressed.

    Arturo Casadevall, Dimitrios P. Kontoyiannis, Vincent Robert
  • Open Access
    Antifungal Activity of the <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Peptide EntV Requires Protease Cleavage and Disulfide Bond Formation
    Editor's Pick Research Article | Therapeutics and Prevention
    Antifungal Activity of the Enterococcus faecalis Peptide EntV Requires Protease Cleavage and Disulfide Bond Formation

    Enterococcus faecalis and Candida albicans are among the most important and problematic pathobionts, organisms that normally are harmless commensals but can cause dangerous infections in immunocompromised hosts. In fact, both organisms are listed by the Centers for Disease Control and Prevention as...

    Armand O. Brown, Carrie E. Graham, Melissa R. Cruz, Kavindra V. Singh, Barbara E. Murray, Michael C. Lorenz, Danielle A. Garsin
  • Open Access
    In Fungal Intracellular Pathogenesis, Form Determines Fate
    Commentary | Host-Microbe Biology
    In Fungal Intracellular Pathogenesis, Form Determines Fate

    For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity.

    Robin C. May, Arturo Casadevall
  • Open Access
    Editor's Pick Research Article | Ecological and Evolutionary Science
    The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination

    Mutations introduce variation into the genome upon which selection can act. Defining the nature of these changes is critical for determining species evolution, as well as for understanding the genetic changes driving important cellular processes. The heterozygous diploid fungus Candida albicans is both a frequent commensal organism and a prevalent opportunistic...

    Joshua M. Wang, Richard J. Bennett, Matthew Z. Anderson

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