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biotechnology

  • Open Access
    RanDeL-Seq: a High-Throughput Method to Map Viral <em>cis</em>- and <em>trans</em>-Acting Elements
    Research Article | Host-Microbe Biology
    RanDeL-Seq: a High-Throughput Method to Map Viral cis- and trans-Acting Elements

    Recent studies have renewed interest in developing novel antiviral therapeutics and vaccines based on defective interfering particles (DIPs)—a subset of viral deletion mutants that conditionally replicate. Identifying and engineering DIPs require that viral cis- and trans-acting elements be accurately mapped.

    Timothy Notton, Joshua J. Glazier, Victoria R. Saykally, Cassandra E. Thompson, Leor S. Weinberger
  • Open Access
    Convergent Evolution of Neutralizing Antibodies to <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> γ-Hemolysin C That Recognize an Immunodominant Primary Sequence-Dependent B-Cell Epitope
    Research Article | Therapeutics and Prevention
    Convergent Evolution of Neutralizing Antibodies to Staphylococcus aureus γ-Hemolysin C That Recognize an Immunodominant Primary Sequence-Dependent B-Cell Epitope

    Staphylococcus aureus infection is a major public health threat in part due to the spread of antibiotic resistance and repeated failures to develop a protective vaccine. Infection is associated with production of virulence factors that include exotoxins that attack host barriers and cellular defenses, such as the leukocidin (Luk) family of bicomponent pore-forming...

    David N. Hernandez, Kayan Tam, Bo Shopsin, Emily E. Radke, Karen Law, Timothy Cardozo, Victor J. Torres, Gregg J. Silverman
  • Open Access
    Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in <em>Pseudomonas putida</em> Lysine Metabolism
    Research Article | Molecular Biology and Physiology
    Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in Pseudomonas putida Lysine Metabolism

    P. putida lysine metabolism can produce multiple commodity chemicals, conferring great biotechnological value. Despite much research, the connection of lysine catabolism to central metabolism in P. putida remained undefined. Here, we used random barcode transposon sequencing to fill the gaps of...

    Mitchell G. Thompson, Jacquelyn M. Blake-Hedges, Pablo Cruz-Morales, Jesus F. Barajas, Samuel C. Curran, Christopher B. Eiben, Nicholas C. Harris, Veronica T. Benites, Jennifer W. Gin, William A. Sharpless, Frederick F. Twigg, Will Skyrud, Rohith N. Krishna, Jose Henrique Pereira, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Adam P. Arkin, Adam M. Deutschbauer, Jay D. Keasling
  • Open Access
    Minireview
    The U.S. Culture Collection Network Responding to the Requirements of the Nagoya Protocol on Access and Benefit Sharing
    Kevin McCluskey, Katharine B. Barker, Hazel A. Barton, Kyria Boundy-Mills, Daniel R. Brown, Jonathan A. Coddington, Kevin Cook, Philippe Desmeth, David Geiser, Jessie A. Glaeser, Stephanie Greene, Seogchan Kang, Michael W. Lomas, Ulrich Melcher, Scott E. Miller, David R. Nobles, Kristina J. Owens, Jerome H. Reichman, Manuela da Silva, John Wertz, Cale Whitworth, David Smith
  • Open Access
    Research Article
    Leucine Biosynthesis Is Involved in Regulating High Lipid Accumulation in Yarrowia lipolytica

    The ubiquitous metabolism of lipids involves refined regulation, and an enriched understanding of this regulation would have wide implications. Various factors can influence lipid metabolism, including the environment and genetics. We demonstrated, using a multi-omics and multifactorial experimental setup, that multiple factors affect lipid accumulation in the yeast Yarrowia lipolytica. Using integrative analysis, we identified...

    Eduard J. Kerkhoven, Young-Mo Kim, Siwei Wei, Carrie D. Nicora, Thomas L. Fillmore, Samuel O. Purvine, Bobbie-Jo Webb-Robertson, Richard D. Smith, Scott E. Baker, Thomas O. Metz, Jens Nielsen
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