biogeography
Research Article | Host-Microbe BiologyBiogeography of the Relationship between the Child Gut Microbiome and Innate Immune SystemBoth the gut microbiome and innate immunity are known to differ across biogeographically diverse human populations. The gut microbiome has been shown to directly influence systemic immunity in animal models.
Research Article | Host-Microbe BiologyInteractions of Symbiotic Partners Drive the Development of a Complex Biogeography in the Squid-Vibrio SymbiosisThe complexity, inaccessibility, and time scales of initial colonization of most animal microbiomes present challenges for the characterization of how the bacterial symbionts influence the form and function of tissues in the minutes to hours following the initial interaction of the partners. Here, we use the naturally occurring binary squid-vibrio association to explore this phenomenon. Imaging of the spatiotemporal landscape of this...
Research Article | Ecological and Evolutionary ScienceCRISPR Spacers Indicate Preferential Matching of Specific Virioplankton GenesThe CRISPR-Cas system is one means by which bacterial and archaeal populations defend against viral infection which causes 20 to 50% of cell mortality in the ocean. We tested the hypothesis that certain viral genes are preferentially targeted for the initial attack of the CRISPR-Cas system on a viral genome. Using CASC, a pipeline for CRISPR spacer discovery, and metagenome data from oceanic microbes and viruses, we found a clear subset...