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bacteria

  • Open Access
    Step-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants
    Research Article | Host-Microbe Biology
    Step-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants

    Within-host evolution has been described in many bacterial diseases, and the genetic basis behind the adaptations has stimulated a lot of interest. Yet, the studied adaptations are generally focused on antibiotic resistance and rarely on the adaptation to the environment given by the host, and the potential trade-offs hindering adaptations to each step of the infection are rarely considered.

    Christian Faucher, Vincent Mazana, Marion Kardacz, Nathalie Parthuisot, Jean-Baptiste Ferdy, David Duneau
  • Open Access
    RIPK3-Dependent Recruitment of Low-Inflammatory Myeloid Cells Does Not Protect from Systemic <em>Salmonella</em> Infection
    Observation | Host-Microbe Biology
    RIPK3-Dependent Recruitment of Low-Inflammatory Myeloid Cells Does Not Protect from Systemic Salmonella Infection

    Macrophages employ multiple strategies to limit pathogen infection. For example, macrophages may undergo regulated cell death, including RIPK3-dependent necroptosis, as a means of combatting intracellular bacterial pathogens. However, bacteria have evolved mechanisms to evade or exploit immune responses. Salmonella is an intracellular pathogen that avoids and manipulates immune detection within macrophages. We examined the...

    John Satkovich, Christopher J. Anderson, Christopher B. Medina, Matteo Ottolini, John R. Lukens, Melissa M. Kendall
  • Open Access
    Interspecies Microbial Fusion and Large-Scale Exchange of Cytoplasmic Proteins and RNA in a Syntrophic <em>Clostridium</em> Coculture
    Editor's Pick Research Article | Molecular Biology and Physiology
    Interspecies Microbial Fusion and Large-Scale Exchange of Cytoplasmic Proteins and RNA in a Syntrophic Clostridium Coculture

    We report that two different bacterial organisms engage in heterologous cell fusion that leads to massive exchange of cellular material, including proteins and RNA, and the formation of persistent hybrid cells. The interspecies cell fusion observed here involves a syntrophic microbial system, but these heterologous cell fusions were observed even under nonstrict syntrophic conditions, leaving open the possibility that strict syntrophy...

    Kamil Charubin, Shannon Modla, Jeffrey L. Caplan, Eleftherios Terry Papoutsakis
  • Open Access
    (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in <span class="named-content genus-species" id="named-content-1">Listeria monocytogenes</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes

    Bacteria must efficiently maintain homeostasis of essential molecules to survive in the environment. We found that the levels of c-di-AMP and (p)ppGpp, two nucleotide second messengers that are highly conserved throughout the microbial world, coexist in a homeostatic loop in the facultative intracellular pathogen Listeria monocytogenes. Here, we found that cyclic di-...

    Bret N. Peterson, Megan K. M. Young, Shukun Luo, Jeffrey Wang, Aaron T. Whiteley, Joshua J. Woodward, Liang Tong, Jue D. Wang, Daniel A. Portnoy
  • Open Access
    A MicroRNA Network Controls <em>Legionella pneumophila</em> Replication in Human Macrophages via LGALS8 and MX1
    Research Article | Host-Microbe Biology
    A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1

    Cases of Legionella pneumophila pneumonia occur worldwide, with potentially fatal outcome. When causing human disease, Legionella injects a plethora of virulence factors to reprogram macrophages to circumvent immune defense and create a replication niche. By analyzing Legionella-induced changes in miRNA expression and genomewide chromatin...

    Christina E. Herkt, Brian E. Caffrey, Kristin Surmann, Sascha Blankenburg, Manuela Gesell Salazar, Anna L. Jung, Stefanie M. Herbel, Kerstin Hoffmann, Leon N. Schulte, Wei Chen, Alexandra Sittka-Stark, Uwe Völker, Martin Vingron, Annalisa Marsico, Wilhelm Bertrams, Bernd Schmeck
  • Open Access
    <em>In Vivo</em> Assay Reveals Microbial OleA Thiolases Initiating Hydrocarbon and β-Lactone Biosynthesis
    Editor's Pick Research Article | Molecular Biology and Physiology
    In Vivo Assay Reveals Microbial OleA Thiolases Initiating Hydrocarbon and β-Lactone Biosynthesis

    Microbially produced β-lactones are found in antibiotic, antitumor, and antiobesity drugs. Long-chain olefinic membrane hydrocarbons have potential utility as fuels and specialty chemicals. The metabolic pathway to both end products share bacterial enzymes denoted as OleA, OleC, and OleD that transform acyl-CoA cellular intermediates into β-lactones. Bacteria producing membrane hydrocarbons via the Ole pathway additionally express a β-...

    Megan D. Smith, Serina L. Robinson, Mandkhai Molomjamts, Lawrence P. Wackett
  • Open Access
    More than Simple Parasites: the Sociobiology of Bacteriophages and Their Bacterial Hosts
    Minireview | Ecological and Evolutionary Science
    More than Simple Parasites: the Sociobiology of Bacteriophages and Their Bacterial Hosts

    Bacteria harbor viruses called bacteriophages that, like all viruses, co-opt the host cellular machinery to replicate. Although this relationship is at first glance parasitic, there are social interactions among and between bacteriophages and their bacterial hosts. These social interactions can take on many forms, including cooperation, altruism, and cheating. Such behaviors among individuals in groups of bacteria have been well...

    Patrick R. Secor, Ajai A. Dandekar
  • Open Access
    RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria
    Research Article | Molecular Biology and Physiology
    RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria

    G-quadruplex in RNA (rG4) mediates various biological functions and cellular processes in eukaryotic organisms. However, the presence, locations, and functions of rG4 are still elusive in prokaryotes. Here, we found that rG4 is an abundant RNA secondary structure across a wide range of bacterial species. Subsequently, the transcriptome-wide rG4 structure sequencing (rG4-seq) revealed that the model...

    Xiaolong Shao, Weitong Zhang, Mubarak Ishaq Umar, Hei Yuen Wong, Zijing Seng, Yingpeng Xie, Yingchao Zhang, Liang Yang, Chun Kit Kwok, Xin Deng
  • Open Access
    Antibiotics and Host-Tailored Probiotics Similarly Modulate Effects on the Developing Avian Microbiome, Mycobiome, and Host Gene Expression
    Research Article | Applied and Environmental Science
    Antibiotics and Host-Tailored Probiotics Similarly Modulate Effects on the Developing Avian Microbiome, Mycobiome, and Host Gene Expression

    Alternative approaches are greatly needed to reduce the need for antibiotic use in food animal production. This study utilized a pipeline for the development of a host-tailored probiotic to enhance performance in commercial turkeys and modulate their microbiota, similar to the effects of low-dose antibiotic administration. We determined that a host-tailored probiotic, developed in the context of the commercial turkey gut microbiome, was...

    Tonya L. Ward, Bonnie P. Weber, Kristelle M. Mendoza, Jessica L. Danzeisen, Katharine Llop, Kevin Lang, Jonathan B. Clayton, Elicia Grace, Jeanine Brannon, Igor Radovic, Mai Beauclaire, Timothy J. Heisel, Dan Knights, Carol Cardona, Mike Kogut, Casey Johnson, Sally L. Noll, Ryan Arsenault, Kent M. Reed, Timothy J. Johnson
  • Open Access
    A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <em>Salmonella</em> Infection
    Research Article | Host-Microbe Biology
    A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

    Salmonella exploits macrophages to gain access to the lymphatic system and bloodstream to lead to local and potentially systemic infections. With an increasing number of antibiotic-resistant isolates identified in humans, Salmonella infections have become major threats to public health. Therefore, there is an urgent need to identify alternative approaches to anti-infective therapy, including host-directed therapies. In...

    Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan

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