azithromycin
Research Article | Clinical Science and EpidemiologyTracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal SalmonellaIn the early 1900s, with mortality of ∼30%, typhoid and paratyphoid (caused by Salmonella Typhi and Paratyphi A) ravaged parts of the world; with improved water, sanitation, and hygiene in resource-rich countries and the advent of antimicrobials, mortality dwindled to <1%. Today, the burden rests disproportionately on South Asia, where the primary means for combatting the disease is antimicrobials.
Research Article | Clinical Science and EpidemiologyGenomic Drivers of Multidrug-Resistant Shigella Affecting Vulnerable Patient Populations in the United States and AbroadMultidrug-resistant Shigella isolates with resistance to macrolides are an emerging public health threat. We define a plasmid/pathogen complex behind infections seen in the United States and globally in vulnerable patient populations and identify multiple outbreaks in the United States and evidence of intercontinental transmission.
Commentary | Therapeutics and PreventionCommensal Bacteria: Not Just Innocent BystandersNeisseria gonorrhoeae is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring.