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azithromycin

  • Open Access
    Tracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal <em>Salmonella</em>
    Research Article | Clinical Science and Epidemiology
    Tracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal Salmonella

    In the early 1900s, with mortality of ∼30%, typhoid and paratyphoid (caused by Salmonella Typhi and Paratyphi A) ravaged parts of the world; with improved water, sanitation, and hygiene in resource-rich countries and the advent of antimicrobials, mortality dwindled to <1%. Today, the burden rests disproportionately on South Asia, where the primary means for combatting the disease is antimicrobials.

    Mohammad S. I. Sajib, Arif M. Tanmoy, Yogesh Hooda, Hafizur Rahman, Jason R. Andrews, Denise O. Garrett, Hubert P. Endtz, Samir K. Saha, Senjuti Saha
  • Open Access
    Genomic Drivers of Multidrug-Resistant <em>Shigella</em> Affecting Vulnerable Patient Populations in the United States and Abroad
    Research Article | Clinical Science and Epidemiology
    Genomic Drivers of Multidrug-Resistant Shigella Affecting Vulnerable Patient Populations in the United States and Abroad

    Multidrug-resistant Shigella isolates with resistance to macrolides are an emerging public health threat. We define a plasmid/pathogen complex behind infections seen in the United States and globally in vulnerable patient populations and identify multiple outbreaks in the United States and evidence of intercontinental transmission.

    Jay Noboru Worley, Kiran Javkar, Maria Hoffmann, Kristen Hysell, Amanda Garcia-Williams, Kaitlin Tagg, Sanjat Kanjilal, Errol Strain, Mihai Pop, Marc Allard, Louise Francois Watkins, Lynn Bry
  • Open Access
    Commensal Bacteria: Not Just Innocent Bystanders
    Commentary | Therapeutics and Prevention
    Commensal Bacteria: Not Just Innocent Bystanders

    Neisseria gonorrhoeae is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring.

    Michael A. Apicella
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