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antimicrobial agents

  • Open Access
    <span class="named-content genus-species" id="named-content-1">Bacillus anthracis</span> Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis
    Research Article | Molecular Biology and Physiology
    Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis

    Compromising the integrity of the bacterial cell barrier is a common action of antimicrobials. Targocil is an antimicrobial that is active against the bacterial envelope. We hypothesized that Bacillus anthracis, a potential weapon of bioterror, senses and responds to targocil to alleviate targocil-dependent cell damage. Here, we show that targocil treatment increases...

    Clare L. Laut, William J. Perry, Alexander L. Metzger, Andy Weiss, Devin L. Stauff, Suzanne Walker, Richard M. Caprioli, Eric P. Skaar
  • Open Access
    Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Research Article | Clinical Science and Epidemiology
    Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae

    In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment of carbapenem-resistant Enterobacteriaceae, the most problematic pathogens in human clinical settings—especially carbapenem-resistant K. pneumoniae....

    Luchao Lv, Miao Wan, Chengzhen Wang, Xun Gao, Qiwen Yang, Sally R. Partridge, Yang Wang, Zhiyong Zong, Yohei Doi, Jianzhong Shen, Peiyao Jia, Qianhua Song, Qianhui Zhang, Jun Yang, Xianhui Huang, Minggui Wang, Jian-Hua Liu
  • Open Access
    Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents
    Research Article | Therapeutics and Prevention
    Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

    We used established methodologies from network science to identify patterns in medicinal ingredient combinations in a key medieval text, the 15th-century Lylye of Medicynes, focusing on recipes for topical treatments for symptoms of microbial infection. We conducted experiments screening the antimicrobial activity of selected ingredients. These experiments revealed interesting examples of ingredients that potentiated or...

    Erin Connelly, Charo I. del Genio, Freya Harrison
  • Open Access
    Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Acute Infection
    Research Article | Host-Microbe Biology
    Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

    Antimicrobial resistance in bacteria represents one of the most consequential problems in modern medicine, and its emergence and spread threaten to compromise central advances in the treatment of infectious diseases. Ceftazidime-avibactam (CZA) belongs to a new class of broad-spectrum beta-lactam/beta-lactamase inhibitor combinations designed to treat infections caused by multidrug-resistant bacteria. Understanding the emergence of...

    Pavel P. Khil, Augusto Dulanto Chiang, Jonathan Ho, Jung-Ho Youn, Jamie K. Lemon, Juan Gea-Banacloche, Karen M. Frank, Mark Parta, Robert A. Bonomo, John P. Dekker
  • Open Access
    Letter to the Editor
    Subversion of Metabolic Wasting as the Mechanism for folM-Linked Sulfamethoxazole Resistance
    Yusuke Minato, Anthony D. Baughn
  • Open Access
    Opinion/Hypothesis
    Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
    Jun-Seob Kim, Thomas K. Wood
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