antimicrobial activity

  • Open Access
    Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery
    Observation | Therapeutics and Prevention
    Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery

    The world faces two seemingly unrelated challenges—a shortfall in the STEM workforce and increasing antibiotic resistance among bacterial pathogens. We address these two challenges with Tiny Earth, an undergraduate research course that excites students about science and creates a pipeline for antibiotic discovery.

    Amanda Hurley, Marc G. Chevrette, Deepa D. Acharya, Gabriel L. Lozano, Manuel Garavito, Jen Heinritz, Luis Balderrama, Mara Beebe, Martel L. DenHartog, Kamiyah Corinaldi, Renee Engels, Alyssa Gutierrez, Orli Jona, Josephine H. I. Putnam, Brody Rhodes, Tiffany Tsang, Simon Hernandez, Carol Bascom-Slack, Jessamina E. Blum, Paul A. Price, Debra Davis, Joanna Klein, Joshua Pultorak, Nora L. Sullivan, Nigel J. Mouncey, Pieter C. Dorrestein, Sarah Miller, Nichole A. Broderick, Jo Handelsman
  • Open Access
    Research Article
    Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi
    Joseph E. Spraker, Philipp Wiemann, Joshua A. Baccile, Nandhitha Venkatesh, Julia Schumacher, Frank C. Schroeder, Laura M. Sanchez, Nancy P. Keller
  • Open Access
    Research Article
    Kisameet Glacial Clay: an Unexpected Source of Bacterial Diversity

    Identifying and characterizing the resident microbial populations (bacteria, viruses, protozoa, and fungi) is key to understanding the ecology, chemistry, and homeostasis of virtually all sites on Earth. The Kisameet Bay deposit in British Columbia, Canada, holds a novel glacial clay with a history of medicinal use by local indigenous people. We previously showed that it has potent activity against a variety of antibiotic-resistant...

    Sarah L. Svensson, Shekooh Behroozian, Wanjing Xu, Michael G. Surette, Loretta Li, Julian Davies
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