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antimicrobial

  • Open Access
    Functional Differences between <span class="named-content genus-species" id="named-content-1">E. coli</span> and ESKAPE Pathogen GroES/GroEL
    Research Article | Molecular Biology and Physiology
    Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL

    The GroES/GroEL chaperonin from E. coli has long served as the model system for other chaperonins. This assumption seemed valid because of the high conservation between the chaperonins.

    Jared Sivinski, Andrew J. Ambrose, Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Niloufar Mollasalehi, Lynn K. Kaneko, Mckayla Stevens, Anne-Marie Ray, Yangshin Park, Chunxiang Wu, Quyen Q. Hoang, Steven M. Johnson, Eli Chapman
  • Open Access
    Novel Antimicrobials from Uncultured Bacteria Acting against <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>
    Research Article | Therapeutics and Prevention
    Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis

    Decreasing discovery rates and increasing resistance have underscored the need for novel therapeutic options to treat Mycobacterium tuberculosis infection. Here, we screen extracts from previously uncultured soil microbes for specific activity against Mycobacterium tuberculosis, identifying three...

    Jeffrey Quigley, Aaron Peoples, Asel Sarybaeva, Dallas Hughes, Meghan Ghiglieri, Catherine Achorn, Alysha Desrosiers, Cintia Felix, Libang Liang, Stephanie Malveira, William Millett, Anthony Nitti, Baldwin Tran, Ashley Zullo, Clemens Anklin, Amy Spoering, Losee Lucy Ling, Kim Lewis
  • Open Access
    Research Article
    Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter baumannii

    Quaternary amine compounds (QACs) are widely used to prevent the spread of bacterial pathogens, but our understanding of their mode of action is incomplete. Here we describe disruption of bacterial proteostasis as an unrecognized action of QAC antimicrobial action and uncover the potential of diverse QAC structures to act as multitarget antibiotics.

    Gregory A. Knauf, Ashley L. Cunningham, Misha I. Kazi, Ian M. Riddington, Alexander A. Crofts, Vincent Cattoir, M. Stephen Trent, Bryan W. Davies
  • Open Access
    Commentary
    Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
    Lance B. Price
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