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antifolate drugs

  • Open Access
    A Solution to Antifolate Resistance in Group B <em>Streptococcus</em>: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim
    Research Article | Therapeutics and Prevention
    A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

    Group B Streptococcus is an important human pathogen that causes serious infections during pregnancy which can lead to chorioamnionitis, funisitis, premature rupture of gestational membranes, preterm birth, neonatal sepsis, and death. GBS is evolving antimicrobial resistance mechanisms, and the work presented in this paper provides evidence that prebiotics such as human milk oligosaccharides can act as adjuvants to restore the...

    Schuyler A. Chambers, Rebecca E. Moore, Kelly M. Craft, Harrison C. Thomas, Rishub Das, Shannon D. Manning, Simona G. Codreanu, Stacy D. Sherrod, David M. Aronoff, John A. McLean, Jennifer A. Gaddy, Steven D. Townsend
  • Open Access
    Letter to the Editor
    Subversion of Metabolic Wasting as the Mechanism for folM-Linked Sulfamethoxazole Resistance
    Yusuke Minato, Anthony D. Baughn
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