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Antibodies, Viral

  • Open Access
    Research Article
    High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks
    Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J. Kucharski, Alexandra Rockstroh, Beate M. Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J. Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
  • Open Access
    Research Article
    Analysis of Individuals from a Dengue-Endemic Region Helps Define the Footprint and Repertoire of Antibodies Targeting Dengue Virus 3 Type-Specific Epitopes
    Daniela V. Andrade, Leah C. Katzelnick, Doug G. Widman, Angel Balmaseda, Aravinda M. de Silva, Ralph S. Baric, Eva Harris
  • Open Access
    Editor's Pick Research Article
    Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

    Influenza viruses are a serious concern for public health and cause a large number of deaths worldwide every year. Current influenza virus vaccines can confer protection from disease, but they often show low efficacy due to the ever-changing nature of the viruses. Novel vaccination approaches target conserved epitopes of the virus, including the hemagglutinin stalk domain, to elicit universally protective antibodies that also bind to...

    Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer
  • Open Access
    Research Article
    Maternal Antiviral Immunoglobulin Accumulates in Neural Tissue of Neonates To Prevent HSV Neurological Disease
    Yike Jiang, Chaya D. Patel, Richard Manivanh, Brian North, Iara M. Backes, David A. Posner, Francesca Gilli, Andrew R. Pachner, Lananh N. Nguyen, David A. Leib
  • Open Access
    Research Article
    Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited

    We previously reported that sialidase activity of human neutrophils plays a critical role in the host inflammatory response. Since the catalytic domains of microbial neuraminidases are highly conserved, we hypothesized that antibodies against Clostridium perfringens neuraminidase might inhibit mammalian sialidase activity. Before the recognition of four mammalian sialidase (Neu) isoforms, we demonstrated that anti-...

    Chiguang Feng, Jihong Li, Greg Snyder, Wei Huang, Simeon E. Goldblum, Wilbur H. Chen, Lai-Xi Wang, Bruce A. McClane, Alan S. Cross
  • Open Access
    Research Article
    In Vivo Imaging of Influenza Virus Infection in Immunized Mice

    Influenza A viruses remain a persistent threat to public health. Vaccination and immunotherapy are effective countermeasures for the control of influenza but must contend with antigenic drift and the risk of resistance to antivirals. Traditional preclinical efficacy studies for novel vaccine and pharmaceutical candidates can be time-consuming and expensive and are inherently limited in scope. In vivo imaging approaches offer...

    Rita Czakó, Leatrice Vogel, Elaine W. Lamirande, Kevin W. Bock, Ian N. Moore, Ali H. Ellebedy, Rafi Ahmed, Andrew Mehle, Kanta Subbarao
  • Open Access
    Research Article
    Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin
    Madhusudan Rajendran, Raffael Nachbagauer, Megan E. Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer
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