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antibodies

  • Open Access
    Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19
    Research Article | Clinical Science and Epidemiology
    Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19

    Results from prior studies assaying human milk for the presence of SARS-CoV-2, the causative virus of COVID-19, have suggested milk may act as a potential vehicle for mother-to-child transmission. Most previous studies are limited because they followed only a few participants, were cross-sectional, and/or failed to report how milk was collected and/or analyzed.

    Ryan M. Pace, Janet E. Williams, Kirsi M. Järvinen, Mandy B. Belfort, Christina D. W. Pace, Kimberly A. Lackey, Alexandra C. Gogel, Phuong Nguyen-Contant, Preshetha Kanagaiah, Theresa Fitzgerald, Rita Ferri, Bridget Young, Casey Rosen-Carole, Nichole Diaz, Courtney L. Meehan, Beatrice Caffé, Mark Y. Sangster, David Topham, Mark A. McGuire, Antti Seppo, Michelle K. McGuire
  • Open Access
    Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier
    Observation | Host-Microbe Biology
    Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier

    HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage. The HIV-1 envelope spike gp160 is partially required for viral transcytosis across the BBB endothelium. But do antibodies developing in infected individuals and targeting the HIV-1 gp160 glycoproteins block HIV-1 transcytosis through the BBB? We addressed this...

    Valérie Lorin, Anne Danckaert, Françoise Porrot, Olivier Schwartz, Philippe V. Afonso, Hugo Mouquet
  • Open Access
    Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies
    Research Article | Therapeutics and Prevention
    Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies

    There is a pressing need for next-generation influenza vaccine strategies that are better able to manage antigenic drift and the cocirculation of multiple drift variants and that consistently improve vaccine effectiveness. Influenza virus NA is a key target antigen as a component of a next-generation vaccine in the influenza field, with evidence for a role in protective immunity in humans. However, mechanisms of protection provided by...

    E. R. Job, T. Ysenbaert, A. Smet, A. Van Hecke, L. Meuris, H. Kleanthous, X. Saelens, T. U. Vogel
  • Open Access
    Further Mechanisms and Locations in Which Antisporozoite Antibodies Neutralize Malaria Sporozoites
    Letter to the Editor | Host-Microbe Biology
    Further Mechanisms and Locations in Which Antisporozoite Antibodies Neutralize Malaria Sporozoites
    Jerome P. Vanderberg
  • Open Access
    Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis
    Research Article | Clinical Science and Epidemiology
    Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis

    The presence in cerebrospinal fluid of antibodies to EV peptides at higher levels than non-AFM controls supports the plausibility of a link between EV infection and AFM that warrants further investigation and has the potential to lead to strategies for diagnosis and prevention of disease.

    Nischay Mishra, Terry Fei Fan Ng, Rachel L. Marine, Komal Jain, James Ng, Riddhi Thakkar, Adrian Caciula, Adam Price, Joel A. Garcia, Jane C. Burns, Kiran T. Thakur, Kimbell L. Hetzler, Janell A. Routh, Jennifer L. Konopka-Anstadt, W. Allan Nix, Rafal Tokarz, Thomas Briese, M. Steven Oberste, W. Ian Lipkin
  • Open Access
    Antibody-Mediated Protection against <em>Plasmodium</em> Sporozoites Begins at the Dermal Inoculation Site
    Research Article | Host-Microbe Biology
    Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site

    Studies in experimental animal models and humans have shown that antibodies against Plasmodium sporozoites abolish parasite infectivity and provide sterile immunity. While it is well documented that these antibodies can be induced after immunization with attenuated parasites or subunit vaccines, the mechanisms by and location in which they neutralize parasites have...

    Yevel Flores-Garcia, Gibran Nasir, Christine S. Hopp, Christian Munoz, Amanda E. Balaban, Fidel Zavala, Photini Sinnis
  • Open Access
    Research Article
    Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection
    Adam J. Pelzek, Bo Shopsin, Emily E. Radke, Kayan Tam, Beatrix M. Ueberheide, David Fenyö, Stuart M. Brown, Qianhao Li, Ada Rubin, Yi Fulmer, William K. Chiang, David N. Hernandez, Hanane El Bannoudi, William E. Sause, Alexis Sommerfield, Isaac P. Thomsen, Andy O. Miller, Victor J. Torres, Gregg J. Silverman
  • Open Access
    Research Article
    IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates
    Anna E. Schager, C. Coral Dominguez-Medina, Francesca Necchi, Francesca Micoli, Yun Shan Goh, Margaret Goodall, Adriana Flores-Langarica, Saeeda Bobat, Charlotte N. L. Cook, Melissa Arcuri, Arianna Marini, Lloyd D. W. King, Faye C. Morris, Graham Anderson, Kai-Michael Toellner, Ian R. Henderson, Constantino López-Macías, Calman A. MacLennan, Adam F. Cunningham
  • Open Access
    Research Article
    Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity
    Melissa Ghulam-Smith, Alex Olson, Laura F. White, Charles S. Chasela, Sascha R. Ellington, Athena P. Kourtis, Denise J. Jamieson, Gerald Tegha, Charles M. van der Horst, Manish Sagar
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