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antibiotics

  • Open Access
    A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens
    Research Article | Host-Microbe Biology
    A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens

    Staphylococcus aureus is a leading agent of antibiotic-resistant bacterial infections in the world. S. aureus tightly controls metal homeostasis during infection, and disruption of metal uptake systems impairs staphylococcal virulence. We identified small molecules that interfere with metal handling...

    Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
  • Open Access
    Micron Scale Spatial Measurement of the O<sub>2</sub> Gradient Surrounding a Bacterial Biofilm in Real Time
    Observation | Molecular Biology and Physiology
    Micron Scale Spatial Measurement of the O2 Gradient Surrounding a Bacterial Biofilm in Real Time

    O2 is a fundamental environmental metabolite that affects all life on earth. While toxic to many microbes and obligately required by others, those that have appropriate physiological responses survive and can even benefit from various levels of O2, particularly in biofilm communities. Although most studies have focused on measuring O2 within biofilms, little is known about O2 gradients...

    Alexander D. Klementiev, Zhaoyu Jin, Marvin Whiteley
  • Open Access
    Bacterial Cell Wall Quality Control during Environmental Stress
    Minireview | Molecular Biology and Physiology
    Bacterial Cell Wall Quality Control during Environmental Stress

    Nearly all bacteria are encased in a peptidoglycan cell wall, an essential polysaccharide structure that protects the cell from osmotic rupture and reinforces cell shape. The integrity of this protective barrier must be maintained across the diversity of environmental conditions wherein bacteria replicate. However, at the cell surface, the cell wall and its synthesis machinery face unique challenges that threaten their integrity....

    Elizabeth A. Mueller, Petra Anne Levin
  • Open Access
    Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
    Research Article | Molecular Biology and Physiology
    Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

    Acyldepsipeptide (ADEP) antibiotics effectively kill multidrug-resistant Gram-positive pathogens, including vancomycin-resistant enterococcus, penicillin-resistant Streptococcus pneumoniae (PRSP), and methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial activity of ADEP depends on a...

    Nadine Silber, Stefan Pan, Sina Schäkermann, Christian Mayer, Heike Brötz-Oesterhelt, Peter Sass
  • Open Access
    Intra-Amniotic Infection with <em>Ureaplasma parvum</em> Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin
    Editor's Pick Research Article | Host-Microbe Biology
    Intra-Amniotic Infection with Ureaplasma parvum Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin

    Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Multiple etiologies are associated with preterm birth; however, 25% of preterm infants are born to a mother with intra-amniotic infection, most commonly due to invasion of the amniotic cavity by Ureaplasma species. Much research has focused on establishing a link between Ureaplasma species and adverse pregnancy/neonatal outcomes; however...

    Kenichiro Motomura, Roberto Romero, Yi Xu, Kevin R. Theis, Jose Galaz, Andrew D. Winters, Rebecca Slutsky, Valeria Garcia-Flores, Chengrui Zou, Dustyn Levenson, Robert Para, Madison M. Ahmad, Derek Miller, Chaur-Dong Hsu, Nardhy Gomez-Lopez
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Burkholderia ubonensis</span> Meropenem Resistance: Insights into Distinct Properties of Class A β-Lactamases in <span class="named-content genus-species" id="named-content-2">Burkholderia cepacia</span> Complex and <span class="named-content genus-species" id="named-content-3">Burkholderia pseudomallei</span> Complex Bacteria
    Research Article | Therapeutics and Prevention
    Burkholderia ubonensis Meropenem Resistance: Insights into Distinct Properties of Class A β-Lactamases in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Bacteria

    Burkholderia pseudomallei causes melioidosis, a tropical disease that is highly fatal if not properly treated. Our data show that, in contrast to B. pseudomallei, B. ubonensis β-lactam resistance is fundamentally different because...

    Nawarat Somprasong, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer
  • Open Access
    Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics
    Research Article | Molecular Biology and Physiology
    Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics

    Uncovering the mechanisms of resistance is a required step for countering the looming antibiotic resistance crisis. In this communication, we show how universally conserved histidine-triad hydrolases provide resistance to microcin C, a potent inhibitor of bacterial protein synthesis.

    Eldar Yagmurov, Darya Tsibulskaya, Alexey Livenskyi, Marina Serebryakova, Yury I. Wolf, Sergei Borukhov, Konstantin Severinov, Svetlana Dubiley
  • Open Access
    Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics
    Research Article | Host-Microbe Biology
    Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

    Human milk is the sole and recommended nutrition for the newborn infant and contains one of the largest constituents of diverse oligosaccharides, dubbed human milk oligosaccharides (HMOs). Preclinical and clinical association studies indicate that HMOs have multiple physiological functions largely mediated through the establishment of the gut microbiome. Until recently, HMOs were not available to investigate their role in randomized...

    Bernard Berger, Nadine Porta, Francis Foata, Dominik Grathwohl, Michèle Delley, Deborah Moine, Aline Charpagne, Léa Siegwald, Patrick Descombes, Philippe Alliet, Giuseppe Puccio, Philippe Steenhout, Annick Mercenier, Norbert Sprenger
  • Open Access
    Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in <span class="named-content genus-species" id="named-content-1">Burkholderia thailandensis</span>
    Research Article | Molecular Biology and Physiology
    Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis

    The discovery of antibiotics ranks among the most significant accomplishments of the last century. Although the targets of nearly all clinical antibiotics are known, our understanding regarding their natural functions and the effects of subinhibitory concentrations is in its infancy. Stimulatory rather than inhibitory functions have been attributed to low-dose antibiotics. Among these, we previously found that antibiotics activate...

    Anran Li, Dainan Mao, Aya Yoshimura, Paul C. Rosen, W. Lance Martin, Étienne Gallant, Martin Wühr, Mohammad R. Seyedsayamdost
  • Open Access
    Long-Term Effects of Early-Life Antibiotic Exposure on Resistance to Subsequent Bacterial Infection
    Research Article | Host-Microbe Biology
    Long-Term Effects of Early-Life Antibiotic Exposure on Resistance to Subsequent Bacterial Infection

    The gastrointestinal microbiota protects hosts from enteric infections; while antibiotics, by altering the microbiota, may diminish this protection. We show that after early-life exposure to antibiotics host susceptibility to enhanced Citrobacter rodentium-induced colitis is persistent and that this enhanced disease susceptibility is transferable by the antibiotic-...

    Claire Roubaud-Baudron, Victoria E. Ruiz, Alexander M. Swan, Bruce A. Vallance, Ceren Ozkul, Zhiheng Pei, Jackie Li, Thomas W. Battaglia, Guillermo I. Perez-Perez, Martin J. Blaser

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