antibiotic resistance
Research Article | Molecular Biology and PhysiologyA Small Regulatory RNA Controls Cell Wall Biosynthesis and Antibiotic ResistanceThe alphaproteobacterium Agrobacterium tumefaciens is able to infect various eudicots causing crown gall tumor formation. Based on its unique ability of interkingdom gene transfer, Agrobacterium serves as a crucial biotechnological tool for genetic manipulation of plant cells. The presence of...
Research Article | Clinical Science and EpidemiologySalmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial ResistanceTyphoid fever, caused by Salmonella enterica serovar Typhi, is responsible for an estimated burden of approximately 17 million new episodes per year worldwide. Adequate and timely antimicrobial treatment invariably cures typhoid fever. The increasing antimicrobial resistance (AMR) of S. Typhi severely limits the treatment options. We studied whole-genome...
Research Article | Ecological and Evolutionary ScienceThe Transferable Resistome of ProduceProduce is one of the most popular food commodities. Unfortunately, leafy greens can be a reservoir of transferable antibiotic resistance genes. We found that IncF and IncI plasmids were the most prevalent plasmid types in E. coli isolates from produce. This study highlights the importance of the rare microbiome associated with produce as a source of antibiotic...
Research Article | Clinical Science and EpidemiologyBacCapSeq: a Platform for Diagnosis and Characterization of Bacterial InfectionsBacCapSeq is a method for differential diagnosis of bacterial infections and defining antimicrobial sensitivity profiles that has the potential to reduce morbidity and mortality, health care costs, and the inappropriate use of antibiotics that contributes to the development of antimicrobial resistance.
- Commentary | Therapeutics and PreventionMosaic Drug Efflux Gene Sequences from Commensal Neisseria Can Lead to Low-Level Azithromycin Resistance Expressed by Neisseria gonorrhoeae Clinical Isolates
In a previous mBio article, Wadsworth and colleagues (mBio 9:e01419-18, 2018, https://doi.org/10.1128/mBio.01419-18) described Neisseria gonorrhoeae isolates that express low levels of azithromycin (Azi) resistance. Whole-genome sequencing and bioinformatic analysis suggested that the isolates had acquired...
- Research ArticleEscherichia coli ST131-H22 as a Foodborne Uropathogen
E. coli ST131 is an important extraintestinal pathogen that can colonize the gastrointestinal tracts of humans and food animals. Here, we combined detection of accessory traits associated with avian adaptation (ColV plasmids) with high-resolution phylogenetics to quantify the portion of human infections caused by ST131 strains of food animal origin. Our results...
- Editor's Pick Research ArticleLow-Level Antimicrobials in the Medicinal Leech Select for Resistant Pathogens That Spread to Patients
- Editor's Pick Research ArticlePredictable Phenotypes of Antibiotic Resistance Mutations
The spread of antibiotic-resistant bacteria imposes an urgent threat to public health. The ability to forecast the evolutionary success of resistant mutants would help to combat dissemination of antibiotic resistance. Previous studies have shown that the phenotypic effects (fitness and resistance level) of resistance mutations can vary substantially depending on the genetic context in which they occur. We conducted a broad screen using...