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  • Topics
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Anti-Bacterial Agents

  • Open Access
    Research Article
    Importance of Core Genome Functions for an Extreme Antibiotic Resistance Trait
    Larry A. Gallagher, Samuel A. Lee, Colin Manoil
  • Open Access
    Editor's Pick Research Article
    Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells

    The recalcitrance of antibiotic-tolerant persister cells is thought to cause relapsing infections and antibiotic treatment failure in various clinical setups. Previous studies identified multiple genetic pathways involved in persister formation but also revealed reproducibility problems that sparked controversies about adequate tools to study persister cells. In this study, we unraveled how typical antibiotic killing assays often fail...

    Alexander Harms, Cinzia Fino, Michael A. Sørensen, Szabolcs Semsey, Kenn Gerdes
  • Open Access
    Research Article
    Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism

    We are just beginning to understand some of the important interactions that occur between microbes of the human gut microbiota that dictate the composition and abundance of its constituent members. The ability of one member to produce molecules that directly kill a coresident member has been shown among minor gut species and is just starting to be studied in the abundant Bacteroides species. Here, we show that some strains of...

    Maria Chatzidaki-Livanis, Michael J. Coyne, Kevin G. Roelofs, Rahul R. Gentyala, Jarreth M. Caldwell, Laurie E. Comstock
  • Open Access
    Research Article
    CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens
    Matthew A. Crawford, Debra J. Fisher, Lisa M. Leung, Sara Lomonaco, Christine Lascols, Antonio Cannatelli, Tommaso Giani, Gian Maria Rossolini, Yohei Doi, David R. Goodlett, Marc W. Allard, Shashi K. Sharma, Erum Khan, Robert K. Ernst, Molly A. Hughes
  • Open Access
    Research Article
    Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering
    Melissa D. Barnes, Marisa L. Winkler, Magdalena A. Taracila, Malcolm G. Page, Eric Desarbre, Barry N. Kreiswirth, Ryan K. Shields, Minh-Hong Nguyen, Cornelius Clancy, Brad Spellberg, Krisztina M. Papp-Wallace, Robert A. Bonomo
  • Open Access
    Research Article
    Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria
    Ganesh Krishnamoorthy, Inga V. Leus, Jon W. Weeks, David Wolloscheck, Valentin V. Rybenkov, Helen I. Zgurskaya
  • Open Access
    Research Article
    Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa
    Peter Jorth, Kathryn McLean, Anina Ratjen, Patrick R. Secor, Gilbert E. Bautista, Sumedha Ravishankar, Amir Rezayat, Jayanthi Garudathri, Joe J. Harrison, Rachel A. Harwood, Kelsi Penewit, Adam Waalkes, Pradeep K. Singh, Stephen J. Salipante
  • Open Access
    Research Article
    Associations among Antibiotic and Phage Resistance Phenotypes in Natural and Clinical Escherichia coli Isolates
    Richard C. Allen, Katia R. Pfrunder-Cardozo, Dominik Meinel, Adrian Egli, Alex R. Hall
  • Open Access
    Research Article
    Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms
    Brett M. Babin, Lydia Atangcho, Mark B. van Eldijk, Michael J. Sweredoski, Annie Moradian, Sonja Hess, Tim Tolker-Nielsen, Dianne K. Newman, David A. Tirrell
  • Open Access
    Research Article
    Quinolone Resistance Reversion by Targeting the SOS Response
    E. Recacha, J. Machuca, P. Díaz de Alba, M. Ramos-Güelfo, F. Docobo-Pérez, J. Rodriguez-Beltrán, J. Blázquez, A. Pascual, J. M. Rodríguez-Martínez

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