TABLE 2 

Single nucleotide polymorphisms detected in M. tuberculosis and M. bovis BCG spontaneous mutants resistant to DG70

StrainDG70 MIC90 (µg/ml)Gene(s) mutatedAmino acid change
H37Rv
    70P3a>80 menG, sigLV20A
    70P7a40 menG, ponA1F118L
    DRM1 >80 menG W75A
    DRM7 >80 menG S188A
BCG
    70B1 19.2 menG A60V
    70B219.2 menG A60V
    70B419.2 menG D7H
    70R19.6 menG G99V
    70R29.6 menG G99V
    70R519.2 menG D7H
    70S1>40 menG R43W
    70S39.6 menG V136F
    70S49.6 menG R190M
  • a Whole-genome-sequenced strains.