TABLE 2 

Single nucleotide polymorphisms detected in M. tuberculosis and M. bovis BCG spontaneous mutants resistant to DG70

StrainDG70 MIC90 (µg/ml)Gene(s) mutatedAmino acid change
H37Rv
    70P3a >80menG, sigLV20A
    70P7a 40menG, ponA1F118L
    DRM1 >80menGW75A
    DRM7 >80menGS188A
BCG
    70B1 19.2menGA60V
    70B219.2menGA60V
    70B419.2menGD7H
    70R19.6menGG99V
    70R29.6menGG99V
    70R519.2menGD7H
    70S1>40menGR43W
    70S39.6menGV136F
    70S49.6menGR190M
  • a Whole-genome-sequenced strains.