↵a Parameters are as follows:

*K*is the first-order rate constant that connects the gut to the bloodstream; SCL is the first-order clearance of fluconazole from the central compartment (i.e., bloodstream);_{a}*V*is the volume of the central compartment; Kcp and Kpc are the first-order intercompartmental rate constants that connect the central and peripheral compartments; Ksc and Kcs are the first-order intercompartmental rate constants that connect the central compartment and CSF;*V*cns is the volume of the CSF;*F*is the oral bioavailability of fluconazole; Kgmax_s and Kgmax_r are the maximum growth rates of the susceptible and resistant subpopulations, respectively; popmax is the maximum theoretical fungal density in the cerebrum; kkmax_s is the maximum rate of fluconazole killing of the susceptible subpopulation in the cerebrum; C_{50}k_s is the cerebral concentration of fluconazole at which the rate of killing of the susceptible subpopulation is half maximal; Hk_s is the slope function for the effect of fluconazole on the susceptible population; kkmax_r is the maximum rate of fluconazole killing of the resistant subpopulation in the cerebrum; C_{50}k_r is the cerebral concentration of fluconazole at which the rate of killing of the resistant subpopulation is half maximal; Hk_r is the slope function for the effect of fluconazole on the resistant population; and IC_s and IC_r are the estimated initial densities of the susceptible and resistant subpopulations in the cerebrum, respectively.