TABLE 3

PK parameters for 16 patients with >1 fluconazole PK data sample available from plasma and CSF

TABLE 3
  • a Parameters are as follows: Ka is the first-order rate constant that connects the gut to the bloodstream, SCL is the first-order clearance of fluconazole from the central compartment (i.e., bloodstream), V is the volume of the central compartment, Kcp and Kpc are the first-order intercompartmental rate constants that connect the central and peripheral compartments, Ksc and Kcs are the first-order intercompartmental rate constants that connect the central and CSF compartments, Vcsf is the volume of the CSF, and F is the oral bioavailability of fluconazole.