TABLE 5

Pharmacodynamic parameters for 11 patients with >1 estimate of fungal density from CSF

• a Parameters are as follows: popmax is the maximum theoretical fungal density in CSF; kkmax_s is the maximum rate of fluconazole killing of the susceptible subpopulation in CSF; C50k_s is the CSF concentration of fluconazole at which the rate of killing of the susceptible subpopulation is half maximal; Hk_s is the slope function for the effect of fluconazole on the susceptible population; Kgmax_r is the maximum rate of growth of the resistant subpopulation; kkmax_r is the maximum rate of fluconazole killing of the resistant subpopulation in CSF; C50k_r is the CSF concentration of fluconazole at which the rate of killing of the resistant subpopulation is half maximal; Hk_r is the slope function for the effect of fluconazole on the resistant population; and Initial Condition_s and Initial Condition_r are the estimated initial densities of the susceptible and resistant subpopulations in the CSF, respectively.