TABLE 2

Classification of identified SAAVs by typea

TABLE 2
  • a Total number of observed single-amino-acid variation (SAAV) putatively caused by mRNA editing events in the 7-day sample. Respective theoretical mass shifts of each amino acid exchange are given. Additionally, percentages of sites found for both the edited as well as the nonedited variant are given. PROVEAN prediction score was retrieved for each individual SAAV via the PROVEAN web interface (70), and the median score for each class of SAAV was calculated. A default threshold of −2.5 was used to estimate the extent of potentially deleterious variants.

  • b N→D events were not considered, as they can be caused by RNA editing as well as by asparagine deamidation on the protein/peptide level.