TABLE 1

siRNA deconvolution validation of nine proviral candidatesa

TABLE 1
  • a Nine proviral candidates were selected for validation with deconvoluted siRNAs. Four individual siRNAs targeting different regions of each gene were used to transfect NHDF cells, followed by infection 48 h posttransfection with HCMV TB40/E-GFP at an MOI of 5. The number of deconvoluted siRNAs that showed the same phenotype as the pool is shown. An individual siRNA was considered validated when knockdown led to significant inhibition of virus replication. Colour gradient associated with mean ratio indicates level of inhibition, with highest to lowest inhibition graded from red to green. n =3.