TABLE 1

Sequence analysis and subcellular localization of MenB-4C vaccine antigensa

Vaccine antigenNEIS no.NmB strains (n = 4)N. gonorrhoeae strains (n = 970)
No. of isolates with full-length proteinPredicted OMPNo. of isolates with full-length proteinPredicted OMP
FHbpNEIS03494+970
NhbANEIS21094+970+
NadANEIS19692+0NA
OMV (PorA)NEIS13644+0NA
GNA2091NEIS20714+970+/–
GNA1030NEIS11834+970+
  • a Cellular localization and signal peptide predictions were determined using the in silico tools BUSCA, Cello2GO, PSORTdb, and SignalP. OMP, outer membrane protein; +, predicted as OMP by at least 2 tools; –, not predicted as OMP by any of the tools; +/–, predicted as OMP by 1 tool; NA, not applicable due to the absence of an ORF.