TABLE 2

Virologic and immunologic correlates of time to viral rebound with adjustment for agee

VariableHR (95% CI)P value
UnadjustedAdjusted
Preselected variables
    Plasma VL at ART starta2.2 (1.24–3.95)0.008NA
    ADCC antibody titer on ARTa1.9 (1.05–3.45)0.034NA
    CD4+ CD69+ T cells on ARTb0.82 (0.26–2.56)0.727NA
    CH505 T/F-neutralizing antibody titer at ART starta2.1 (0.82–5.57)0.119NA
Exploratory variables
    Virologic and humoral responses
        Peak plasma VLa1.39 (0.86–2.27)0.1820.364
        CH505 gp120-specific IgG pre-ARTa4.61 (1.38–15.42)0.01310.066
        CH505 gp120-specific IgG on ARTa6.06 (1.33–27.54)0.01970.066
        Tier 1 MW965-neutralizing antibody pre-ARTa4.12 (1.42–11.96)0.009260.066
        sCD4-blocking antibodies pre-ARTc1.07 (1–1.13)0.04020.1
    CD4+ T cell phenotypes and inflammatory responses
        CD4+ T cells pre-ARTb0.97 (0.86–1.1)0.660.81
        CD4+ T cells on ARTb0.99 (0.9–1.09)0.770.82
        HLA-DR+ CD4+ T cells on ARTb1 (1–1)0.710.81
        Ki67+ CD4+ T cells on ARTb1 (0.98–1.05)0.40.8
        PD-1+ CD4+ T cells on ARTb1 (1–1)0.320.8
        G-CSF on ARTb1.1 (0.91–1.28)0.360.8
        IL-12 on ARTd1.1 (0.96–1.36)0.130.8
        IL-15 on ARTd0.77 (0.4–1.5)0.450.8
        IL-18 on ARTd0.97 (0.93–1.01)0.150.8
        IL-1RA on ARTd1 (0.99–1.01)0.710.81
        IL-8 on ARTd1 (1–1)0.970.97
        MCP-1 on ARTd1 (0.99–1.02)0.340.8
        MIP-1α on ARTd0.68 (0.3–1.57)0.370.8
        TNF-α on ARTd0.91 (0.79–1.04)0.170.8
        VEGF on ARTd0.97 (0.86–1.1)0.640.81
        sCD40L on ARTd1 (1–1)0.70.81
  • a Values are expressed as log10.

  • b Values are expressed as absolute counts per nanoliter of blood.

  • c Values are expressed as percentages.

  • d Values are expressed as concentrations in picogram/milliliter (pg/mL).

  • e HR, hazard ratio; CI, confidence interval; NA, not applicable since multiple adjustment was not performed on preselected parameters.