TABLE 2

Differentially expressed E. coli UTI89 genes after treatment with 30 nM B22a

Change and
gene ID
Log2
fold
change
P valueKEGG functionGene
Increased expression
    UTI89_C17604.388.39E−53c-di-GMP diguanylate cyclaseydeH
    UTI89_C16692.964.39E−09DNA-binding transcriptional regulatormcbR
    UTI89_C20442.854.39E−09DNA polymerase III subunit thetaholE
    UTI89_C13042.561.02E−26Prophage endopeptidasearrD
    UTI89_C48482.241.57E−14Enamine/imine deaminaseyjgF (ridA)
    UTI89_C13032.142.39E−05Prophage lysozymeybcS1
    UTI89_C22391.922.20E−03Hypothetical proteinyaiS
    UTI89_C36441.908.86E−05Peptidoglycan glycosyltransferasemtgA
    UTI89_C01241.891.30E−06Hypothetical proteinorf
    UTI89_C01651.852.82E−12Peptidoglycan synthasemrcB
    UTI89_C36701.802.91E−04Ribonuclease inhibitoryhcO
    UTI89_C04531.801.57E−13Hypothetical proteincyoD
    UTI89_C13481.771.51E−03Hypothetical proteinymgA
    UTI89_C40481.741.30E−03Transcriptional regulatorgadX
    UTI89_C10511.672.70E−04Cold shock proteincspG
    UTI89_C11721.631.36E−03Periplasmic glucan biosynthesis proteinmdoG
    UTI89_C03381.571.17E−03Type 1 fimbria regulatory proteinfimX
    UTI89_C10951.478.77E−04Hypothetical proteinorf
    UTI89_C40971.443.98E−04Cold shock proteincspA
    UTI89_C25411.441.21E−08Undecaprenyl phosphate-l-ara4N flippase subunitarnF (yfbJ)
    UTI89_C11521.409.36E−10Hypothetical proteinorf
    UTI89_C01301.392.93E−05Hypothetical proteinyacH
    UTI89_C18701.345.84E−05Peptidoglycan d-transpeptidaseynhG
    UTI89_C00261.324.08E−09Hypothetical proteinyaaY
    UTI89_C31821.314.40E−09Hypothetical proteinygdI
    UTI89_C08801.315.86E−07ATP-dependent endonucleaseybjD
    UTI89_C31811.301.36E−04Hypothetical proteinygdI
    UTI89_C27021.301.83E−03Two-component system acid-sensing sensor kinaseevgS
    UTI89_C23031.291.31E−03Hypothetical proteinwbgM
    UTI89_C18331.297.20E−08Transcriptional regulator of multiple antibiotic resistancemarR
    UTI89_C16041.285.63E−06Universal stress protein EuspE
    UTI89_C18991.275.87E−07Hypothetical proteinydiU
    UTI89_C06861.222.49E−05Hypothetical proteinybfN
    UTI89_C05051.204.83E−03Inosine kinasegsk
    UTI89_C44811.133.04E−06Hypothetical proteinfdoG
    UTI89_C32361.123.41E−05Hypothetical proteinygdR
    UTI89_C33301.116.56E−07Hypothetical proteinyqgD
    UTI89_C05661.114.49E−03Outer membrane proteinompT
    UTI89_C45541.112.19E−03Hydrogen peroxide-inducible transcriptional activatoroxyR
    UTI89_C46161.102.83E−04Fur family transcriptional regulatoryjbK
    UTI89_C39281.103.73E−03Hypothetical proteinorf
    UTI89_C37361.091.95E−04Ribosome rescue factoryhdL
    UTI89_C12861.094.26E−03Hypothetical proteinorf
    UTI89_C45211.081.74E−0450S ribosomal subunit protein L31rpmE
    UTI89_C11691.044.75E−03Cardiolipin synthaseymdC
    UTI89_C20771.038.93E−04Cytochrome c trimethylamine-N-oxide reductasetorY
    UTI89_C37241.022.07E−05Hypothetical proteinyrdA
Decreased expression
    UTI89_C2748−1.061.64E−03Hypothetical proteinptsK
    UTI89_C2386−1.091.18E−03Hypothetical proteinyehE
    UTI89_C2497−1.115.14E−03Outer membrane pore protein CompC
    UTI89_C3587−1.141.92E−03Hypothetical proteinyhbW
    UTI89_C1622−1.158.31E−05Heat shock protein HslJhslJ
    UTI89_C2016−1.161.97E−06Mannose-specific enzyme IIC component of PTSmanY
    UTI89_C4503−1.161.76E−03Triosephosphate isomerasetpiA
    UTI89_C1002−1.192.19E−03Asparaginyl-tRNA synthetaseasnS
    UTI89_C2472−1.194.17E−03Cytochrome c-type biogenesis protein CcmHccmH
    UTI89_C3842−1.221.78E−03Elongation factor GfusA
    UTI89_C4647−1.253.42E−05c-di-GMP phosphodiesteraseyjcC
    UTI89_C1537−1.272.04E−0323S rRNA pseudouridine synthaseyciL
    UTI89_C4739−1.271.33E−04Amino acid efflux transporteryjeH
    UTI89_C0608−1.352.27E−03Peroxiredoxin hydroperoxide reductase subunit CahpC
    UTI89_C3746−1.361.49E−04Preprotein translocase subunitsecY
    UTI89_C4299−1.382.48E−03Aspartate-ammonia ligaseasnA
    UTI89_C2011−1.395.23E−03c-di-GMP phosphodiesteraseardB
    UTI89_C2753−1.414.31E−03Hypothetical proteinyfeK
    UTI89_C2302−1.411.03E−036-Phosphogluconate dehydrogenasegnd
    UTI89_C4380−1.482.31E−03Hypothetical proteinorf
    UTI89_C1019−1.482.79E−033-Hydroxyacyl-[acyl-carrier protein] dehydratasefabA
    UTI89_C5174−1.551.24E−03Two-component system response regulatorarcA
    UTI89_C2387−1.642.58E−03ATP-binding protein involved in chromosome partitioningmrp
    UTI89_C0972−1.663.04E−06Major facilitator superfamily transporterycaD
    UTI89_C3582−1.707.37E−07EndonucleaseyhbQ
    UTI89_C4612−1.715.00E−05Diacylglycerol kinasedgkA
    UTI89_C4742−1.762.36E−03Hypothetical proteinyjeI
    UTI89_C4754−1.785.48E−04Fumarate reductasefrdA
    UTI89_C1779−1.821.21E−09Chloride channel proteinynfJ
    UTI89_C2583−1.884.06E−05NUDIX hydrolaseyfcD
    UTI89_C2573−1.892.63E−055'-DeoxynucleotidaseyfbR
    UTI89_C3050−1.928.00E−07GlutaredoxingshA
    UTI89_C3862−1.977.31E−04N-Succinyldiaminopimelate aminotransferasedapC
    UTI89_C2471−2.021.39E−09Two-component system response regulatornarP
    UTI89_C3148−2.024.78E−07Enolaseeno
    UTI89_C0216−2.024.12E−03d,d-Heptose 1,7-bisphosphate phosphatasegmhB
    UTI89_C3686−2.106.18E−07Hypothetical proteinyrdE
    UTI89_C3411−2.159.56E−10Disulfide bond oxidoreductase and hydroperoxidaseyghU
    UTI89_C3167−2.212.41E−05Serine transportersdaC
    UTI89_C2105−2.293.03E−03Hypothetical proteinyecR
    UTI89_C0908−2.293.74E−04Seryl-tRNA synthetaseserS
    UTI89_C4736−2.311.94E−13Aspartate ammonia-lyaseaspA
    UTI89_C2517−2.344.73E−07FerredoxinyfaE
    UTI89_C1975−2.348.86E−08Glyceraldehyde 3-phosphate dehydrogenasegapA
    UTI89_C3253−2.372.08E−03Xanthine dehydrogenasexdhC
    UTI89_C4151−2.451.22E−03Protein export proteinsecB
    UTI89_C2480−2.528.86E−04Cytochrome c-type protein NapCnapC
    UTI89_C2754−2.604.23E−04Cysteine synthasecysM
    UTI89_C4735−2.639.23E−04Anaerobic C4-dicarboxylate transporterdcuA
    UTI89_C0624−2.711.45E−08Two-component response regulatorcitB
    UTI89_C0974−2.716.40E−12Formate acetyltransferasepflB
    UTI89_C4840−2.738.22E−10Soluble cytochrome b562cybC
    UTI89_C3920−2.901.14E−05RNA 3'-terminal phosphate cyclasertcA
    UTI89_C0333−2.931.27E−07Inner membrane proteinykgH
    UTI89_C4753−2.971.06E−04Fumarate reductasefrdB
    UTI89_C3168−3.164.37E−04l-Serine dehydratasesdaB
    UTI89_C3346−3.267.14E−13l-AsparaginaseansB