TABLE 1

Baseline study characteristics of the patient samplesa

Study groupNo. of samplesSex (% male)Age range (median)Collection yrSample no.CSFSerumNote(s)EV PCR/typing result
Detected pathogenSuspected pathogen (stool)
CSFPaired seraCSFbRespiratory specimen
AFM1310691–7 yr (3 yr)2018AFM_1YYNegEV-D68Neg
AFM_2YYNegEV-D68NA
AFM_4YNNegNANA
AFM_5YYNegNegNA
AFM_6YNNegNANA
AFM_8YYNegNegNeg
AFM_12YYNegNegCVA4
AFM_13YNNegNANeg
AFM_14YYNegNegCVA9
AFM_17YYNegEV-D68Neg
AFM_18YYNegNANA
AFM_19YYNegRV-A81Neg
AFM_20YYNegNegNA
11FemaleAdult2018AFM_7YYEV-A71NegEV-A71
NAC52600.8–81 yr (11 yr)2018Non_AFM_3YYCause unknownNegNANeg
Non_AFM_9YNWest Nile caseNegNANA
Non_AFM_10YNTransverse myelitisNegNAE-9
Non_AFM_11YYLongitudinally extensive myelitisNegNegNeg
Non_AFM_16YNE-25E-25E-25
10Female152019AC-KT-076YNAutoimmune encephalitisNANANA
KDC108552–36 mo (6.8 mo)2006KD_824YYNANANA
1999KD_98YNNANANA
2007KD_3340YYNANANA
2008KD_3424YYNANANA
2018KD_3589YYNANANA
2018KD_183068YYNANANA
2018KD_183041YYNANANA
2019KD_193017YYNANANA
2008KD_3355YNNANANA
2005KD_3181YYNANANA
AC1154521–73 yr (45.8 yr)2018AC-KT-010YNViral meningitis, unspecified (A87.9)NANANA
2018AC-KT-012YYPossible viral meningitisNANANA
2018AC-KT-017YYSystemic lupus erythematosusNANANA
2018AC-KT-021YNCryptococcal meningitisNANANA
2018AC-KT-023YYPMLNANANA
2018AC-KT-024YNMyalgia, CA of prostate, squamous cell carcinoma lung, neoplasia following lung transplant, muscle pain likely secondary to cetuximab infusionNANANA
2018AC-KT-025YYUnspecified epilepsyNANANA
2018AC-KT-029YYStiff person syndromeNANANA
2018AC-KT-030YNMultiple sclerosisNANANA
2018AC-KT-042YNMultiple sclerosisNANANA
2018AC-KT-049YYDemyelinating disease—likely multiple sclerosisNANANA
  • a All samples were deidentified and met criteria for nonhuman subject research at Columbia University and the University of California, San Diego. For samples contributed by CDC, the work was determined by the CDC National Center for Immunization and Respiratory Diseases to constitute public health surveillance rather than human subject research. Y, yes; N, no; Neg, negative; NA, not available; PML, progressive multifocal leukoencephalopathy.

  • b Combined results of PCR-based EV testing performed by the CDC and CII of Columbia University.