TABLE 2

Effect of loss of PmrA on colistin susceptibility and PmrB mutations in the strain panel

Strain designationColistin MIC (μg/ml)aPmrB mutations (amino acid substitutions)
Wild typeΔpmrA
ATCC 179780.250.25Reference
BV946432Wild type
BV95320.5L274W
BV1722561Q43L and L267F
BV1731281A138T and A226V
BV174641Q277R
BV1752560.5L267W
BV1852560.25P233S
BV186160.25Q277R
BV187160.25Q277R
BV1896464Wild type
BV1902560.5A138T and A226V
BV1912560.25A138T and P233S
  • a Susceptibility breakpoint, ≤2 μg/ml. Susceptible, italics; resistant, bold.