TABLE 1

Genes repressed by MtsR with differential regulation in the vaginal tract

GeneNameDescriptionFold changeaP valueb
spy49_0247pbp7d-Alanyl–d-alanine carboxypeptidase2.40.00565
spy49_0339nrdF.2Ribonucleotide reductase432.033.60E−27
spy49_0340nrdIRibonucleotide reductase stimulatory protein1079.156.20E−20
spy49_0341nrdE.2Ribonucleotide diphosphate reductase245.771.80E−29
spy49_0381mtsAMetal ABC transporter, substrate binding6.231.10E−19
spy49_0382mtsBMetal ABC transporter, ATP binding1.830.00791
spy49_0383mtsCMetal ABC transporter, permease2.240.0007
spy49_0661hupYAdhesion and heme receptor27.261.10E−21
spy49_0662hupZEnzyme, heme degradation37.698.40E−17
spy49_1159cmanBPhosphoglucomutase, phosphomannomutase13.353.20E−19
spy49_1374cdnaKChaperone protein3.050.01803
spy49_1395csiaHECF transporter, A component2.560.00283
spy49_1396csiaGECF transporter, T component2.70.00464
spy49_1397csiaFECF transporter, S component4.712.70E−08
spy49_1398csiaEPutative ABC transporter7.034.10E−10
spy49_1400csiaDPutative ABC transporter12.496.10E−09
spy49_1401csiaCHeme ABC transporter, ATP binding15.684.90E−07
spy49_1402csiaBHeme ABC transporter, permease10.821.90E−07
spy49_1403c/
1404cc
siaA/shpHeme ABC transporter, substrate binding/streptococcal heme-associated protein20.583.80E−08
spy49 _1405cshrStreptococcal hemoprotein receptor25.464.10E−12
spy49_1687cprsAFoldase144.617.43E−17
  • a Fold upregulation in the vaginal tract compared to liquid growth.

  • b False discovery rate-corrected P value.

  • c Annotation of NZ131 incorrectly lists spy49_1403c (siaA) and spy49_1404c (shp) as a single fused gene product rather than two distinct genes.