TABLE 7

Kinetic parameters of β-lactamase inhibition by ETX2514

DrugKi app
(µM)
k2/Ki
(M−1 s−1)
koff (residence
time) (s−1)
koff (residence
time half-life)
(min)
Kd
(nM)
kcat/kinact
ADC-70.11 ± 0.011.0 ± 0.1 × 1068 ± 1 × 10−414 ± 11 ± 0.11
OXA-580.39 ± 0.042.5 ± 0.3 × 1051.6 ± 0.3 × 10−472 ± 81 ± 0.21