TABLE 6

Change in log10 CFU/g burden in thigh tissue 24 h after initiation of therapy to CD-1 mice

Group IDDose (mg/kg)Route/regimenLog10 CFU/gSDChange in
log10 CFU/g
T = Rxn/an/a6.60.23
26-h infection controlVehicleSC/q3h10.00.193.4
Sulbactam75SC/q3h9.00.222.5
ETX251450SC/q3h8.80.312.2
ETX2514-sulbactam12.5:75SC/q3h6.60.490.01
ETX2514-sulbactam50:75SC/q3h5.60.34−1.0
ETX2514-sulbactam200:75SC/q3h5.10.23−1.5
Colistin40SC/q24h5.30.33−1.4