TABLE 4

Genomic changes in mating products after passage in fluconazole

Mating
product/progeny
Fluconazole
MIC (µg/ml)
Genomic change(s) in
mating product
progenya
EM18
EM1P3A-164Loss of wild-type MRR1, wild-type ERG11, and MTLα
EM1P8A-1128Loss of wild-type MRR1, wild-type ERG11, and MTLα
EM1P8A-3128Loss of wild-type MRR1, wild-type ERG11, and MTLα
ME14
ME1P4A-232Loss of wild-type MRR1
ME1P4A-332Loss of wild-type MRR1
ME1P5A-264Loss of wild-type MRR1
ET18
ET1P2A-216
ET1P7A-332Loss of wild-type TAC1-1, decrease in ERG11* and MTLa
TE14
TE1P6A-116Decrease in wild-type TAC1, ERG11*, and MTLα
TE1P6A-216Loss of wild-type TAC1, ERG11*, and MTLα
TE1P12A-1128Loss of wild-type TAC1, increase in ERG11* and MTLα
EU14
EU1P6A-332Decrease in wild-type ERG11 and MTLα
EU1P8A-364Loss of wild-type ERG11 and MTLα, increase in UPC2*
UE12
UE1P2A-14Increase in UPC2*
UE1P4A-316Increase in UPC2*, ERG11*, and MTLα
MT18
MT1P3A-316Decrease in wild-type MRR1
MT1P5A-232Loss of wild-type MRR1
MT1P5A-332Loss of wild-type MRR1, wild-type TAC1, and MTLa
TM14
TM1P6A-216Loss of wild-type TAC1 and MTLα
TM1P6A-316Loss of wild-type TAC1 and MTLα
TM1P10A-164Loss of wild-type MRR1, wild-type TAC1, and MTLα
MU14
MU1P5A-132Decrease in wild-type MRR1
MU1P7A-164Loss of wild-type MRR1
UM14
UM1P3A-332Loss of wild-type MRR1, increase in UPC2*
UM1P3A-164Loss of wild-type MRR1
TU14
TU1P6A-316
TU1P11A-164Loss of wild-type TAC1 and MTLα, increase in UPC2*
TU1P11A-364Loss of wild-type TAC1 and MTLα, increase in UPC2*
UT18
UT1P2A-216Decrease in wild-type TAC1 and MTLa, increase in UPC2*
UT1P2A-316Decrease in wild-type TAC1 and MTLa, increase in UPC2*
UT1P5A-132Loss of wild-type TAC1 and MTLa
UT1P5A-232Decrease in wild-type TAC1 and MTLa, increase in UPC2*
  • a Decreases and increases in copy number are relative to the other allele.