Patient clinical symptoms and initial testing resultsa

Case classification
or leading
No. of days
of illness
to limb
weakness onset
CSF white
blood cells/mm3
No. of
MRI result(s)
13.5Confirmed AFMRespiratory,
2501, LUET2 signal abnormalities in anterior
and posterior columns of the central
gray cervical cord
210Confirmed AFMRespiratory51504T2 signal abnormality with anterior
and posterior involvement,
contiguous through multiple levels
of the cord
34Confirmed AFMRespiratory,
22073, BUE, RLET2 signal abnormality in the anterior
horn of the central gray cord
49Confirmed AFMGI, fever21154Anterior horn signal abnormality
extending four cervical levels
512Probable AFMRespiratory1071, LUENormal
612UnknownNoneNA52, BLET3–T7, T11–T12 gray matter affected
071, RUEC4, C6, T11 gray/white matter affected
817NMORespiratory10222, BLEC3–C7, T1, T10–T11 gray/white matter affected
96.5GBSNoneNA12, BLENormal
1014MS/ADEMGI652, BLEC1–C5, C7, T1, T4–T6, T11–T12
gray/white matter affected
111.5UnknownGI, fever002, BLET4–T7 gray/white matter affected;
edema of conus
  • a Diagnoses reflect whether the AFM case definition was met (confirmed AFM or probable AFM) or not, in which case the leading differential diagnosis at the time of data abstraction was recorded. MRI results for the patients who met the AFM case definitions are those described by the CDC neurology subject matter expert, while MRI results for patients who did not meet the AFM case definitions are those described by the attending radiologist. Other specimen testing included PCR for herpes simplex virus, West Nile virus, human herpesvirus 6, Epstein Barr virus, and Mycoplasma pneumoniae, as well as serology for West Nile virus and the VDRL test for syphilis (20). AFM, acute flaccid myelitis; ADEM, acute disseminated encephalomyelitis; NMO, neuromyelitis optica; GBS, Guillain-Barré syndrome; MS, multiple sclerosis; LUE, left upper extremity; BUE, bilateral upper extremity; RLE, right lower extremity; BLE, bilateral lower extremity; RUE, right upper extremity; NA, not applicable; GI, gastrointestinal.