TABLE 2

Grx4-regulated genes encoding iron transport and homeostasis and mitochondrial functions

Result for iron level comparisona:
Gene IDGene
name
FunctionWT low
vs high
grx4 low
vs WT low
grx4 high
vs WT high
grx4 low
vs high
Iron transport
    CNAG_00815SIT1Siderochrome-iron uptake transporter1.861.062.090.94
    CNAG_06761SIT3Siderophore-iron transporter Str12.290.370.890.96
    CNAG_07387SIT4Siderophore-iron transporter2.813.9210.551.04
    CNAG_07519SIT5Siderophore-iron transporter2.230.642.070.68
    CNAG_07751SIT6Siderophore iron transporter MirB3.632.328.351.00
    CNAG_03498FRE201Metalloreductase1.452.063.390.88
    CNAG_06524FRE3Ferric reductase2.505.0716.250.77
    CNAG_06976FRE6Ferric reductase2.400.661.161.35
    CNAG_00876FRE7Ferric reductase0.400.890.490.72
    CNAG_03498FRE8Ferric reductase1.452.063.390.88
    CNAG_04864CIR1Iron regulator 10.810.020.011.23
    CNAG_01242HAPXConserved hypothetical protein1.931.212.141.08
    CNAG_02950GRX4Grx4 family monothiol glutaredoxin1.720.110.151.21
    CNAG_00727MMT2Mitochondrial protein with role in iron
accumulation
0.500.890.431.04
    CNAG_03465LAC1Laccase 10.9910.227.551.32
    CNAG_05154CCC1Membrane fraction protein0.575.205.500.54
    CNAG_07519SIT1/ARN1Conserved hypothetical protein2.230.642.070.68
    CNAG_01653CIG1Cytokine inducing-glycoprotein, putative
a hemophore
2.290.641.321.10
    CNAG_07865Ferro-O2-oxidoreductase2.550.941.991.20
Heme biosynthesis
    CNAG_01721HEM3Porphobilinogen deaminase0.152.621.710.22
    CNAG_02460HEM13Coproporphyrinogen III oxidase0.390.820.271.16
    CNAG_03939HEM15-Aminolevulinic acid synthase0.192.521.100.42
    CNAG_03187HEM14Protoporphyrinogen oxidase0.920.450.450.91
    CNAG_01908HEM4Uroporphyrinogen-III synthase0.0410.602.720.14
Mitochondrial ISC
assembly
    CNAG_03395NFU1NifU-like protein C0.103.781.590.25
    CNAG_03589YAH1Adrenodoxin-type ferredoxin0.542.242.220.54
    CNAG_02522MRS3/4Carrier1.250.851.110.95
    CNAG_03985GRX5Monothiol glutaredoxin-50.451.952.040.43
    CNAG_05199SSQ1Heat shock protein0.410.810.520.64
    CNAG_04288JAC1Conserved hypothetical protein1.780.340.601.01
    CNAG_02131ISA1Iron sulfur assembly protein 10.322.201.580.44
    CNAG_00491ISA2Iron sulfur assembly protein 20.920.700.820.77
    CNAG_00389IBA57Mitochondrial protein0.252.421.170.52
Cytosolic ISC
assembly
    CNAG_04202NAR1Iron hydrogenase0.153.041.610.28
    CNAG_01802DRE2Cytoplasmic protein0.503.102.410.63
    CNAG_01137ACO1Aconitase0.211.471.350.23
ISC-containing proteins
    CNAG_07908ACO2Aconitate hydratase0.205.642.130.53
    CNAG_06621BIO2Biotin synthase0.351.280.980.45
    CNAG_00462CIR2Oxidoreductase0.058.511.350.29
    CNAG_01914COQ11Mitochondrial protein0.980.580.561.00
    CNAG_07572ELP3Pol II transcription elongation factor0.272.901.760.44
    CNAG_04862GLT1Glutamate synthase0.227.367.150.22
    CNAG_07491GRX6Conserved hypothetical protein1.060.710.920.82
    CNAG_00237LEU13-Isopropylmalate dehydratase0.229.543.010.70
    CNAG_05194LIP5Lipoic acid synthetase0.471.892.160.41
    CNAG_02565LYS4Homoaconitate hydratase0.078.811.640.40
    CNAG_05070MET5Sulfite reductase beta subunit0.143.602.130.23
    CNAG_03206NTG2DNA-(apurinic or apyrimidinic site) lyase0.233.501.890.42
    CNAG_02315RIP1Ubiquinol-cytochrome c reductase iron-sulfur
subunit
0.222.471.300.42
    CNAG_07667SAT4Other/HAL protein kinase0.890.920.830.98
    CNAG_07356SHH3Succinate dehydrogenase0.162.191.130.32
    CNAG_06558TAH18NADPH-ferrihemoprotein reductase0.813.201.821.41
Electron transport
    CNAG_05318CYB2l-Mandelate dehydrogenase0.412.781.840.61
    CNAG_05169CYB2Cytochrome b20.214.541.860.50
    CNAG_07480MCR1Cytochrome b5 reductase2.240.951.671.27
    CNAG_00716CYC7Electron carrier0.222.141.960.23
    CNAG_03666Acyl-CoA dehydrogenase0.062.831.160.14
    CNAG_03629YHB1NADH-ubiquinone oxidoreductase0.054.301.150.20
    CNAG_01229CYB2l-Mandelate dehydrogenase0.133.912.050.25
    CNAG_05631NADH-ubiquinone oxidoreductase0.075.401.290.30
    CNAG_01078ALD5Aldehyde dehydrogenase1.512.393.001.20
    CNAG_04189SDH1Succinate dehydrogenase flavoprotein subunit0.171.521.030.24
    CNAG_04521Oxidoreductase1.401.832.541.00
    CNAG_03663CYB2l-Lactate dehydrogenase0.103.021.310.24
    CNAG_03226SDH2Succinate dehydrogenase iron-sulfur subunit0.091.480.870.15
    CNAG_05179QCR2Ubiquinol-cytochrome c reductase complex core0.172.120.950.37
    CNAG_05258Glucose-methanol-choline oxidoreductase5.684.7217.361.53
    CNAG_01323QCR7Ubiquinol-cytochrome c reductase0.273.201.960.43
    CNAG_05909CYT1Electron transporter0.123.181.180.32
Mitochondrial functions
    CNAG_00162Alternative oxidase0.0252.561.800.68
    CNAG_03824MIR1Phosphate transport protein MIR11.190.260.311.00
    CNAG_00499Carnitine/acyl carnitine carrier0.361.701.040.59
    CNAG_05909Electron transporter0.123.181.180.32
    CNAG_02315Ubiquinol-cytochrome c reductase0.222.471.300.42
    CNAG_05132Cytochrome c oxidase0.481.140.950.56
    CNAG_03225Malate dehydrogenase0.910.560.441.14
    CNAG_002373-Isopropylmalate dehydratase0.229.543.010.70
    CNAG_03596Dihydrolipoamide succinyltransferase0.460.870.740.54
    CNAG_07908Aconitate hydratase0.205.642.130.53
    CNAG_05031Succinyl-CoA:3-ketoacid-coenzyme A transferase0.960.220.650.32
    CNAG_06138NADH dehydrogenase (ubiquinone) Fe-S 60.222.051.010.45
DNA repair
    CNAG_07552RAD8DNA repair Rad80.876.754.971.17
    CNAG_00178REV1DNA repair REV11.406.127.121.19
    CNAG_05198RAD7DNA repair RAD71.275.497.270.95
    CNAG_02544SWI5DNA repair Swi5/Sae31.565.067.041.10
    CNAG_02512RAD16DNA repair RAD161.974.848.861.06
    CNAG_01163RAD54DNA repair and recombination RAD541.243.423.981.06
    CNAG_00299RAD5DNA repair RAD50.752.822.190.96
    CNAG_02771RAD54bDNA repair and recombination RAD54B1.107.918.790.98
    CNAG_00720RAD51DNA repair RAD511.517.1110.720.99
    CNAG_03637Double-strand break repair factor and silencing regulator1.093.613.711.05
Ergosterol metabolism
    CNAG_00519ERG32.180.240.391.30
    CNAG_01129ERG71.660.430.541.32
    CNAG_00854ERG22.460.250.571.08
    CNAG_02830ERG41.820.460.940.88
    CNAG_01737ERG252.190.170.351.06
Oxidative stress
    CNAG_00575CAT3Catalase 3 (CAT3)0.485.593.310.81
    CNAG_00654SRX1Conserved hypothetical protein (SRX1, sulfiredoxin)4.344.8514.411.45
    CNAG_01138CCP1Cytochrome c peroxidase (CCP1)0.07181.0027.350.44
    CNAG_03482TSA1Thioredoxin-dependent peroxide reductase (TSA1)1.315.104.621.44
    CNAG_03985GRX5Monothiol glutaredoxin-5 (GRX5)0.451.952.040.43
    CNAG_04388SOD2Mitochondrial superoxide dismutase Sod20.980.580.511.12
    CNAG_05847TRR1Thioredoxin-disulfide reductase (TRR1)1.2412.1210.131.47
  • a The numbers in boldface are the measurements where the log2 value is ≥2; the numbers in italic are log2 values of <0.5.