TABLEĀ 6

Mutations detected in DNA gyrase (gyrA and gyrB genes) and topoisomerase IV (parC and parE genes) individually, and combined mutation profiles based on them

GeneMutationNo. of
mutations
Mutation combination (profile)No. of
mutation profiles
gyrAD538N352gyrA-D538N, gyrA-S83F179
S83F299gyrA-D538N, gyrA-S83Y120
S83Y125gyrA-S83F66
D87N30gyrA-S83F, parE-A364V26
N529S17parE-A364V18
D87G11gyrA-N529S, gyrB-S464F17
D87Y4gyrA-D87N, parE-A364V15
A119E1gyrA-D538N, gyrA-D87N12
D87A1gyrA-D538N, gyrA-S83F, parE-T447A9
gyrBS464F21gyrA-D538N8
S464Y10gyrA-D538N, gyrA-D87G, gyrA-S83F, parC-E84K8
parCE84K10gyrB-S464Y8
S80R2gyrB-S464F3
D69A2gyrA-D538N, gyrA-D87Y2
T620M1gyrB-S464Y, parE-A364V2
E84G1gyrA-D87Y2
S80I1gyrA-S83Y, parC-D69A, parE-A364V2
parEA364V69gyrA-D538N, gyrA-S83F, parE-L416F2
T447A9gyrA-D87N, parE-A364V, parE-S339L2
L416F2gyrA-D538N, gyrA-S83Y, parE-A365S2
S339L2gyrA-D538N, gyrA-S83F, parC-E84K2
A365S2Other combination pattern (one isolate for each)13
L502F1No mutation18
E460K1
Total536