TABLE 4 

Antibiotic IC50s of the WT and Rv0078 strains

DrugIC50 for:
Parental strainΔRv0078::hyg mutant
Ethionamide1.0–2.3 µg/ml0.8–1.3 µg/ml
Ciprofloxacin0.1–0.2 µg/ml0.1–0.2 µg/ml
Ethambutol0.6–2 µg/ml0.6–2 µg/ml
Isoniazid32–44 ng/ml29–44 ng/ml
Meropenema1 µg/ml1 µg/ml
Norfloxacin2 µg/ml2 µg/ml
Rifampin32–38 ng/ml32–38 ng/ml
Streptomycin0.3–0.6 µg/ml0.3–0.4 µg/ml
Vancomycina3–10 µg/ml6–10 µg/ml
  • a Supplemented with 5 µg/ml potassium clavalunate. See Materials and Methods for details.