TABLE 1 

Vaccine candidates used in this study

AntigenFunctionInactive formReference(s)
ADIArginine deiminase.ADI D277A7, 12
TFRibosome-associated chaperone. Important for protease secretion and activation.7, 8
SLOPore-forming cytolysin. Binds and damages cell membranes, resulting in lysis of the host cell.SLO P427L W535F8, 13
SpyCEPSerine protease cleaves IL-8, interfering with neutrophil recruitment to the site of infection.SpyCEP D151A S617A8, 14, 35
SCPASubtilisin-like protease. Cleaves C5a, interfering with neutrophil recruitment to the site of infection.SCPA D130A S512A8, 15, 33
J812-amino-acid peptide from the C-repeat region of M protein.17, 36, 57, 68
ΔGACGroup A carbohydrate lacking N-acetylglucosamine (GlcNAc) side chain.18