TABLE 2 

Clade-specific SNPs identified between clades C1 and C2

SNP position in EC958SNP in cladea:ImpactbLocus tagCodonGeneProduct
C0C1C2
C001JJ2244G213CD306
426936CCCCCTV→AEC958_0513295sbmAPeptide antibiotic transporter SbmA
737849GGGGGA
2838072GGGGGASynEC958_2841190iscSCysteine desulfurase
2878095CCCCCTE→GEC958_2875229lepAGTP-binding elongation factor LepA
3710995CCCCCTSynEC958_4822302acrFAcriflavine resistance protein F
3905668CCCCCTS→PEC958_3870451nikANickel-binding periplasmic protein
4100042CCCCTC
4397873GGGGAGS→NEC958_4314395rmuCDNA recombination protein RmuC
  • a Boldface indicates clade C1 specific, and italic indicates clade C2 specific.

  • b Impact of SNP in bold relative to ST131 clade C2 strain EC958. Syn, synonymous change; non-synonymous changes to protein-coding genes are shown by single letter amino acid codes (EC958 sequence on left, SNP impact on right); blank lines indicate SNP in intergenic region.