TABLE 1 

Genes positively regulated 6 h postinfection

LocusGene nameFold changeFunctiona
UTI89_C4028chuA13.6170702OM hemin receptor
UTI89_C403012.62532234Hypothetical protein
UTI89_C3064srlA8.533024788PTS, glucitol/sorbitol-specific IIC2 component
UTI89_C4027chuS8.363228798Putative hemin/Hb transport protein
UTI89_C2178ybtS6.132778168Salicylate synthase
UTI89_C4033chuT5.365860462Putative periplasmic binding protein with FepB/HutB regions
UTI89_C1122iroB5.215178967Putative glucosyl transferase
UTI89_C1995yeaR4.653666496Hypothetical protein
UTI89_C0599ybdB4.367933273Paal_thioesterase—tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for PA, phenylacetic acid PA degradation in bacteria
UTI89_C05873.658836126MbtH-like protein (domain found in antibiotic synthesis proteins)
UTI89_C1994yoaG3.380447626Hypothetical protein
UTI89_C5112ybcS23.232487202Bacteriophage lambda lysozyme-like protein
UTI89_C3386gspC2.910385132Putative type II secretion protein GspC
UTI89_C1336sitD2.890235424Transmembrane subunit, of PBP-dependent ABC transporters involved in siderophore uptake
UTI89_C11622.870128155Hypothetical protein
UTI89_C0371lacZ2.52590251Beta-d-galactosidase
UTI89_C51392.265412569Hypothetical protein
UTI89_C4087yhjX2.237949848Putative resistance protein (formate/oxalate antiporter)
UTI89_C46542.114337921Hypothetical protein
UTI89_C2656hkbM2.097069502Hypothetical protein
UTI89_C40322.055215359Hypothetical protein
  • a OM, outer membrane; PTS, phosphotransferase system; Hb, hemoglobin; CoA, coenzyme A; PBP, periplasmic binding protein; ABC, ATP-binding cassette.