TABLE 1 

Responses to inoculation with live H. ducreyi 35000HPa

Volunteer no.,
gender
No. of days
infected
Site
no.
Inoculum
(CFU)
Clinical
endpoint
Induration size and presence of pustule(s) on
postinoculation dayb:
125Endpoint
395, F7132R6 × 6 (−)9 × 9 (−)RR
2P6 × 6 (−)8 × 9 (−)4 × 4 (−)4 × 4 (+)
3P5 × 5 (−)5 × 8 (−)4 × 4 (−)4 × 4 (+)
396, F13132R3 × 3 (−)4 × 4 (−)6 × 7 (−)R
2RNDNDNDND
3RNDNDNDND
398, M6163P5 × 5 (−)5 × 6 (−)9 × 7 (+)10 × 15 (+)
2P4 × 4 (−)5 × 5 (−)5 × 5 (+)6 × 6 (+)
3P5 × 5 (−)5 × 5 (−)6 × 5 (+)5 × 6 (+)
391A, M7163R4 × 4 (−)RRR
2R2 × 2 (−)2 × 2 (−)RR
3R3 × 3 (−)4 × 4 (−)3 × 2 (−)R
406, M6169R2 × 2 (−)2 × 2 (−)RR
2P4 × 4 (−)3 × 3 (−)4 × 4 (+)5 × 5 (+)
3P4 × 4 (−)3 × 3 (−)15 × 7 (+)7 × 7 (+)
407, M9169R4 × 4 (−)5 × 5 (−)RcR
2R4 × 4 (−)5 × 5 (−)RR
3R4 × 4 (−)5 × 5 (−)RR
408, F8135R2 × 2 (−)3 × 3 (−)3 × 3 (−)R
2R4 × 4 (−)RRR
3R3 × 3 (−)RRR
409, M7135P3 × 3 (−)3 × 3 (−)8 × 8 (+)12 × 10 (+)
2R3 × 3 (−)2 × 2 (−)RR
3P4 × 4 (−)5 × 4 (−)5 × 5 (+)12 × 12 (+)
  • a Abbreviations: F, female; M, male; ND, no disease; R, resolved; P, pustule.

  • b Induration dimensions are reported in millimeters; + and − symbols in parentheses indicate the presence or absence of pustules, respectively.

  • c Subject 407 did not achieve the endpoint on day 5 because disease was present at sites injected with the mutant strain.