TABLE 1 

Top 10 significantly enriched, nonambiguous Pfam domains (q value, <0.05) identified across each lineage(s)

LineagePfam accession no.Pfam descriptiona,bq valuec
VGI specificPF02301.13HORMA (HORMA domain)3.62E−08
PF01794.14Ferric reduct (ferric reductase-like transmembrane component)1.27E−06
PF08022.7FAD binding 8 (FAD-binding domain)2.29E−06
PF03151.11TPT (triose-phosphate transporter family)3.85E−06
PF08030.7NAD binding 6 (ferric reductase NAD-binding domain)5.42E−06
PF00098.18zf-CCHC (zinc knuckle)1.02E−05
PF00628.24PhD (PhD-finger)3.92E−05
PF01408.17GFO IDH MocA (oxidoreductase family, NAD-binding Rossmann fold)1.37E−04
PF00005.22ABC tran (ABC transporter)3.02E−03
PF04982.8HPP (HPP family)7.59E−03
VGI-VGIII specificPF00098.18zf-CCHC (zinc knuckle)5.58E−13
PF00160.16Pro isomerase (cyclophilin-type peptidyl-prolyl cis-trans isomerase/CLD)9.37E−12
VGI-VGIII lostPF00070.22Pyr redox (pyridine nucleotide- disulfide oxidoreductase)8.55E−17
PF07110.6EthD (EthD domain)3.04E−12
PF07992.9Pyr redox 2 (pyridine nucleotide- disulfide oxidoreductase)1.17E−15
VGIII specificPF05970.9PIF1 (PIF1-like helicase)a1.07E−02
VGIII lostPF03952.11Enolase N (enolase, N-terminal domain)4.68E−43
PF00113.17Enolase C (enolase, C-terminal TIM barrel domain)4.21E−42
PF01176.14eIF-1a (translation initiation factor 1A/IF-1)1.68E−35
PF07766.8LETM1 (LETM1-like protein)a1.68E−35
PF02627.15CMD (carboxymuconolactone decarboxylase family)1.61E−33
PF00732.14GMC oxred N (GMC oxidoreductase)3.76E−28
PF05199.8GMC oxred C (GMC oxidoreductase)3.76E−28
PF07476.6MAAL C (methylaspartate ammonia-lyase C terminus)1.13E−27
PF00199.14Catalase (catalase)3.39E−25
PF06628.7Catalase-rel (catalase-related immune responsive)3.39E−25
VGIV specificPF13650.1Asp protease 2 (aspartyl protease)7.38E−03
VGIV lostPF07883.6Cupin 2 (Cupin domain)1.51E−44
PF01758.11SBF (sodium bile acid symporter family)1.08E−22
PF02678.11Pirin (Pirin)1.08E−22
PF00190.17Cupin 1 (Cupin)6.01E−22
PF04145.10Ctr (Ctr copper transporter family)6.01E−22
PF13344.1Hydrolase 6 (haloacid dehalogenase- like hydrolase)1.42E−20
PF13242.1Hydrolase-like (HAD-hydrolase-like)1.47E−18
PF00702.21Hydrolase (haloacid dehalogenase-like hydrolase)4.10E−15
PF00631.17G-gamma (GGL domain)5.09E−08
VGII specificPF04144.8SCAMP (SCAMP family)4.21E−16
PF13865.1FoP duplication (C-terminal duplication domain of Friend of PRMT1)4.21E−16
PF00722.16Glyco hydro 16 (glycosyl hydrolase family 16)2.32E−12
PF02567.11PhzC-PhzF (phenazine biosynthesis-like protein)2.32E−12
PF02893.15Gram (GRAM domain)2.32E−12
PF05071.11NDUFA12 (NADH ubiquinone oxidoreductase subunit NDUFA12)2.32E−12
PF00326.16Peptidase S9 (prolyl oligopeptidase family)9.61E−11
PF00657.17Lipase GDSL (GDSL-lik lipase/acylhydrolase)9.61E−11
PF02441.14Flavoprotein (flavoprotein)9.61E−11
PF01619.13Pro dh (proline dehydrogenase)1.30E−10
VGII lostPF02170.17PAZ (PAZ domain)1.05E−24
PF02171.12Piwi (Piwi domain)1.05E−24
PF11790.3Glyco hydro ml (glycosyl hydrolase catalytic core)6.10E−19
PF01902.12ATP bind 4 (ATP-binding region)a1.13E−16
PF00784.12MyTH4 (MyTH4 domain)6.24E−15
PF02897.10Peptidase S9 N (prolyl oligopeptidase, N-terminal beta-propeller domain)6.24E−15
PF08660.6Alg14 (oligosaccharide biosynthesis protein Alg14-like)6.24E−15
PF12862.2Apc5 (anaphase-promoting complex subunit 5)6.24E−15
PF00141.18Peroxidase (peroxidase)5.18E−11
PF01713.16Smr (smr domain)5.18E−11
  • a Domains belong to genes with homology to essential genes in Saccharomyces cerevisiae, and similar nucleotide sequence was detected in the corresponding C. gattii genome using tBLASTn.

  • b Abbreviations: FAD, flavin adenine dinucleotide; HAD, haloacid dehalogenase.

  • c Corrected P values were calculated from the two-tailed Fisher exact test with q-value FDR.