TABLE 1 

Genes located within recombination regions 1 to 6 and associated single nucleotide polymorphismsa

RegionGeneFunctionNo. of mutationsAA change(s)
SNSTotal/total in region
1pbpb1bPenicillin binding protein729/23Ile430Val, Val537Ile
rpoBDNA-directed RNA polymerase14014/23
200183Hypotheticalprotein123/130Arg3Iso,Ala67Val
purAAdenylosuccinate synthetase45550/130Gly84Ala, Thr213Ala, Leu348Phe, Lys351Glu, Tyr355His
00185Nucleoside-binding protein516/130Ala332Thr
nusGTranscription antitermination protein303/130
ngaNAD glycohydrolase11617/130Ala99Val, His103Arg, Arg136Gly, His143Gln, Met221Iso, Gln253His
ifsImmunity factor for SPN/NGA224/130Gly7Ser, Ala136Val
sloStreptolysin O15823/130Thr39Ala, Iso59Thr, Ala130Thr, Met172Arg, Asp182Asn, Asp324Glu, Thr450Ser, Arg470Gln
metBCystathionine beta-lyase213/130Val241Ala
300285d-Alanyl-d-alanine carboxypeptidase628/9Iso27Met, Tyr364Gln
dacA.1d-Alanyl-d-alanine carboxypeptidase101/9
4lacR.2Lactose phosphotransferase system repressor909/16
501551ABC transporter ATP-binding protein505/9
01552ABC transporter224/9Asp269Gly, Asp408Gly
601673Zn-dependent peptidase112/15Iso169Val
01677Hypothetical protein134/15Thr67Iso, Iso83Met, Gln115Lys
recFDNA replication and repair protein448/15Ala59Glu, Gln246His, Asn263Asp, Val363Iso
  • a Abbreviations: S, synonymous; NS, nonsynonymous; AA, amino acid (position in relation to reference H293 strain).