TABLE 2 

HTS hits and Kd values as obtained from fluorescence polarization and IC50s of HTS hits obtained from luciferase assay dose-response curves

HTS hitKd (µM) for Rgg3IC50 (nM)a
SHP2-C80.22
Cyclosporine A0.45203.3
Valspodar0.55251.5
Telmisartan8.3NT
Simvastatin9.7>10 µM
Saquinavir mesylate8.5>10 µM
Olmesartan19.8NT
  • a NT, not tested.