TABLE 2 

Phenotypes measured in the CC lines

PhenotypeResult measuredOrgan(s) analyzed
Clinical diseaseWeight loss, clinical scoreWhole mouse
Viral replicationViral loadSpleen, kidney, brain
Innate immune responseIFN-β, IFIT1Spleen, kidney, brain
HistologyInflammatory infiltratesSpleen, brain
T-cell responseAntigen-specific and bystander activation, short-lived effector cells and memory precursors, Treg activation, T-cell activation and trafficking, cytokine response, CD4 and CD8 T-cell memory responseSpleen, brain
Humoral responseWNV-specific IgG and IgM ELISASerum
Immune responseGene expression profilingSpleen, brain