TABLE 2 

BqsRS guards against cationic but not anionic stressorsa

StrainMIC90StressorStressor's
charge
5 µM Fe(II)75 µM Fe(II)
PA142 (µg/ml)1–2 (µg/ml)Tobramycin+
ΔbqsR mutant1 (µg/ml)0.25 (µg/ml)Tobramycin+
PA14256–512 (µg/ml)8–16 (µg/ml)Cefsulodin
ΔbqsR mutant256 (µg/ml)8 (µg/ml)Cefsulodin
PA142–4 mM2–4 mMHArO4
ΔbqsR mutant2–4 mM2–4 mMHArO4
PA14250 µM250–500 µMCrO4
ΔbqsR mutant250 µM250–500 µMCrO4
  • a MIC assays were performed for the WT and ΔbqsR strains under anaerobic conditions at two different iron concentrations for tobramycin, cefsulodin, arsenate, and chromate. Numbers in bold highlight where the absence of BqsR makes a difference.