TABLE 3 

Neutralization potency of human MAbs, as tested in two cell lines

50% neutralization concentration (EC50)a in indicated
cell type against DENV of indicated serotype (D1 to D4)
MAbU937+DC-SIGN cellsVero-81 cells
D1D2D3D4D1D2D3D4
1M70.550.30.020.50.10.030.072
1N50.10.23>0.10.020.020.01
1C190.060.030.0430.030.010.010.05
1C180.2>>>0.70.223
1L627160.20.020.50.2
1N854860.30.121
3B422120.10.040.40.4
4E80.40.23>NDNDNDND
5C812130.20.030.40.3
  • a The concentration (µg/ml) at which 50% of virus was neutralized (EC50) is shown for each DENV serotype: 50% neutralization values between 1.0 and 10.0 µg/ml are shown in lightface roman, 50% neutralization values of <1.0 µg/ml are shown in bold, and 50% neutralization values of <0.1 μg/ml are shown in bold italic. The “>” symbol indicates that neutralization was not detected even when tested at a concentration as high as 10 µg/ml. ND, not done.