Rate of engulfment of live C. albicans cells by macrophages and PMNsa

PhagocytesAvg rate of engulfment (min ± SD)
C. albicans cell/phagocyte MOI of 1C. albicans cell/phagocyte MOI of 3Coculture assay
Macrophages12.0 ± 1.38.1 ± 0.4b14.4 ± 0.6c
PMNs2.9 ± 0.6d2.1 ± 0.4d1.7 ± 0.2d
  • a Average times (min) taken ± SD for human monocyte-derived macrophages and human PMNs to engulf live wild-type C. albicans cells (n = 3).

  • b The value for macrophages was significantly different at an MOI of 3 (P < 0.01) from the value at an MOI of 1 when macrophages were incubated alone with C. albicans.

  • c The value for macrophages in coculture was significantly different (P < 0.0001) from that for macrophages incubated alone at an MOI of 3.

  • d Values for PMNs were significantly different (P < 0.0001) from those for macrophages at the same MOI.